HEM6_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM6_DROME
• UniProt AC: Q9V3D2
• Protein Name: Oxygen-dependent coproporphyrinogen-III oxidase
• Gene Name: Coprox
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 390
• Protein Description: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity)..
• Protein Sequence: MNALRHTISLVSLGTFQLVRRTRGPHARGFLLGTGLGLASFSAVTYAHSAEAVDPKVNGVQMNTSRFMAEPITDSKALLGDKENMRHRMEILIMEIQAEFCRALEAEENCGQKFKVDRWERPEGGGGITCVLQDGDVFEKAGVNISVVTGSLPPAAVQQMRARGKNLKEGASLPFFASGVSAVIHPRNPHVPTIHFNYRYFEVETAKGEKQWWFGGGTDLTPYYLCEKDASHFHQTLKSACDEHDPTYYPRFKKWCDDYFRIKHRNESRGIGGIFFDDIDSPNQEAAFNFVSSCARAVIPSYVPLVRKHKNREYGNNERQWQLLRRGRYVEFNLIYDRGTKFGLYTPGARYESILMSLPLHARWEYMHEPKSQSEEGKLMKVLKNPKDWV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
172	Phosphorylation	KNLKEGASLPFFASG CCCCCCCCCCCEECC	47.64	22817900
341	Acetylation	LIYDRGTKFGLYTPG EEEECCCCCEEECCC	40.01	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEM6_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM6_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DORS_DROME	dl	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.