| UniProt ID | DORS_DROME | |
|---|---|---|
| UniProt AC | P15330 | |
| Protein Name | Embryonic polarity protein dorsal | |
| Gene Name | dl | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 999 | |
| Subcellular Localization | Cytoplasm. Nucleus. In ventral regions it is first cytoplasmic, then the protein is relocalized in the nucleus. Its nuclear localization is essential to its function as a morphogen. In dorsal regions it remains cytoplasmic. Tamo negatively regulates | |
| Protein Description | Embryonic developmental protein. [PubMed: 2598266] | |
| Protein Sequence | MFPNQNNGAAPGQGPAVDGQQSLNYNGLPAQQQQQLAQSTKNVRKKPYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPYRPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSHRFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKAMSDLVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLDAKREVQPPTIEVIDLDTPKIDVQREIPSEMEFNHEESQQSEPALEQEQSVQQEQYTQEQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLPDHTSDHIPEDMEAADAHAEAEAHRLRSEQEKEIDTIIDEKVRELEQLDLGQQLEPRPLTANDKITEWMKSSEIEQQVHEPSPTAEADVLDSALEISKADKTLDELLETVAELDEIYTDFKVQRDTYKNTIQNELAGLQGRAPLQVEDSFDDAATYTSLQIAFKNPVLIPMDDIMPPTPPMSQCAPEDAHQHYDPVEVNSQARKPETPMRPVPPVPPAILTIQYPPEEDKLPPLPPKRIRKQDSNAENRSIEANTVQTKPSTGESPLNKRLPPAPKNPNFNTLPRQKKPGFFSKLFSRRKSKPDLAQGQENSSILDSKANSREPSIGHFNMQDPMRASLRSSKSAAPFISNPAPAKSSPVKAKKPGSKLTKPVGRSVSSVSGKRPAYLNADVVHIPLKGDSVNSLPQQQRTEGYSQSSTISVGAGLDRRTASALQLADIPISEGGMELVAIADRQSLHNLVSSIEGHFNVQLDPNLDLTEAEHFALYTSIPPLAAASEFDETSAYYAPVDAGEILTPDEVAKRLAAANGI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 312 | Phosphorylation | FIQLRRPSDGVTSEA EEEEECCCCCCCCCC | 45.22 | 10072384 | |
| 317 | Phosphorylation | RPSDGVTSEALPFEY CCCCCCCCCCCCCEE | 20.61 | 10072384 | |
| 382 (in isoform 2) | Sumoylation | - | 42.01 | - | |
| 388 (in isoform 2) | Phosphorylation | - | 38.97 | 25749252 | |
| 389 (in isoform 2) | Phosphorylation | - | 12.49 | 19429919 | |
| 540 | Phosphorylation | KITEWMKSSEIEQQV HHHHHHHHHHHHHHH | 19.66 | 28490779 | |
| 541 | Phosphorylation | ITEWMKSSEIEQQVH HHHHHHHHHHHHHHC | 36.76 | 28490779 | |
| 551 | Phosphorylation | EQQVHEPSPTAEADV HHHHCCCCCCHHHHH | 31.72 | 28490779 | |
| 553 | Phosphorylation | QVHEPSPTAEADVLD HHCCCCCCHHHHHHH | 41.28 | 28490779 | |
| 665 (in isoform 2) | Phosphorylation | - | 13.49 | 19429919 | |
| 770 | Phosphorylation | KLFSRRKSKPDLAQG HHHCCCCCCCCHHCC | 47.84 | 27794539 | |
| 786 | Phosphorylation | ENSSILDSKANSREP CCCHHHHHCCCCCCC | 30.17 | 27794539 | |
| 813 | Phosphorylation | ASLRSSKSAAPFISN HHHHCCCCCCCCCCC | 31.45 | 27794539 | |
| 826 | Phosphorylation | SNPAPAKSSPVKAKK CCCCCCCCCCCCCCC | 41.82 | 27794539 | |
| 827 | Phosphorylation | NPAPAKSSPVKAKKP CCCCCCCCCCCCCCC | 32.76 | 27794539 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 312 | S | Phosphorylation | Kinase | PKA | - | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DORS_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DORS_DROME !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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