TAMO_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAMO_DROME
• UniProt AC: Q9W1A4
• Protein Name: Protein tamozhennic
• Gene Name: tamo
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 797
• Subcellular Localization: Cytoplasm .
• Protein Description: Has an essential role during oogenesis and embryogenesis, perhaps in modulating the levels of nuclear import of additional proteins. Modulates the nuclear import of dorsal (dl), Dif and male specific lethal 1 (msl-1). Negatively regulates nuclear import of dl and controls the accumulation of dl in the nucleus after immune challenge..
• Protein Sequence: MSDFVPHDLIPDLWDEILRRHWMFLETEESIEKLEERKQLEGCLKEFLCVVQHDRKFFLPETGHVLRRSVLELPDFSAQNAIVAFETISQYANNLFTKPWRKEYRTLKTYSGCFQHDIQSRLLDAEQLFLAMGYRRAAEDTFVLEGPICPDQVTNVSRDAMAAYVECQIMKHIYAGVTAAGYVCTWKDILQFRERYVGGTSTTIKEMVRQLSEKRVRMEQPPMQENTYSNVVSAAPTACGMRSNNVAHHPSSSGTCALHPNGLNEAGKYLPPYPAPPPQQPHLPGPLMTHSRSLDHYQEPQAHLPHRHSFDQQLQQQCQLPHVYEAPYDCLDGLSMGSSASYAAVTGAYNAPGNRYPLPYNISSQLNAPYASPADFYGNGQHTNMYATLGKTGPAHSCDLHRRQPNTSAAAAAALAAMQHRQSTYPPDHHLIDFDERAHLTQHDFGTHDYDPQYAELRGQVQPSMRGNPVAMYATYGGYDLPTTLPQAPPPTGQDMYIYARPVPKSSRMRALAEAGGINSTDKHPRSAEKQSTMDNNRKMHKELKERNSRTAPAKRSGTERDIPTTISDLNSYDSASLDGFVALDSSSSPPLMPKVQEGVGSFESWNYVFKNLERSGYTKDLGDREDLLVQSLDLGSLSITNGGAAPPAEKRREATNPTNGEKARTLDKKSGTGRREAKVVQAPAPSPLPNSSSAGVKKVKSALKTAVVDNRGTGSRQRTGAVPKQPPNVSPQLIVTSPNEWSCSFCTFLNPDTKRICEMCCRSKDFNLEAASAASSSAAAAAASAASVSHASSTCV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
293	Phosphorylation	PLMTHSRSLDHYQEP CCCCCCCCCCCCCCC	40.96	21082442
397	Phosphorylation	GKTGPAHSCDLHRRQ CCCCCCCCCCCCCCC	16.07	21082442
441	Phosphorylation	FDERAHLTQHDFGTH CCCCCCCCCCCCCCC	17.62	21082442
608	Phosphorylation	GSFESWNYVFKNLER CCHHHHHHHHHHHHH	10.87	18281928
714	Phosphorylation	AVVDNRGTGSRQRTG HEECCCCCCCCCCCC	28.84	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAMO_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAMO_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAMO_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXD_DROME	exd	physical	14605208
WEK_DROME	wek	physical	14605208
ZFY26_DROME	CG5270	physical	14605208
NUP54_DROME	Nup54	physical	14605208
VTU2_DROME	Vm26Ab	physical	14605208
RANL_DROME	Ran-like	physical	12653959
RAN_DROME	Ran	physical	12653959
DORS_DROME	dl	physical	12653959
NUP88_DROME	mbo	physical	12653959
MSL1_DROME	msl-1	physical	12653959
TAMO_DROME	tamo	physical	12653959

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.