dbPTM

WEK_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WEK_DROME
UniProt AC	Q9VJN5
Protein Name	Zinc finger protein weckle
Gene Name	wek {ECO:0000312\|EMBL:AAF53484.1, ECO:0000312\|FlyBase:FBgn0001990}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	470
Subcellular Localization	Cell membrane . Localizes to the plasma membrane in embryos when bound to Myd88.
Protein Description	Acts as an adapter to assemble/stabilize a Toll/wek/Myd88/tube complex; required for efficient recruitment of Myd88 to Toll. Dispensable for innate immune response; plays a minimal role, if any, in the immune defense against Gram-positive bacteria and fungi. Involved in dorsoventral axis determination..
Protein Sequence	MGVPTSDWIYWCRLCARDDVVYKVRERDDDLVRIISKCFDVEMTLEEPELGSMLCEECYSVIGQLITFSDSVSKVQAIFELLRHSEPQDSQDLDALRLEYGLPPACKQDLEFLDIDDTEDRCSLVEELTISDHSTSPSPDFEAQTVRTRANLKQCNSDPKVLASPTASIPEVETKRSRRQQFAAKRNSKVYTATESDDEEAILDEDEAVSPPPLKRKRGRPKGSGKQKNVDDSDNVTSREPDDNAKSKQDDKTSELSMSPHGSQSSNFVDYPCKICNETFMSFMALRRHKHDMHGGPKKYVCDHCGKGLKTFTSLVEHQLVHTEEKPCICPVCNAGFKNKARLRVHSQTHGEPKFECNVCGKKLQTRAILNKHKYVHTDERRFKCEVCGSGCKNSTALKIHLLGHTGLRPYVCKYCGKAFASNTNCRSHKWKKHPELASKEDETESSRVPVPTLEELRAITREMAKAKQD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
164	Phosphorylation	SDPKVLASPTASIPE CCCCCCCCCCCCCCH	20.72	19429919
166	Phosphorylation	PKVLASPTASIPEVE CCCCCCCCCCCCHHH	30.46	19429919
168	Phosphorylation	VLASPTASIPEVETK CCCCCCCCCCHHHCH	40.95	19429919
233	Phosphorylation	KQKNVDDSDNVTSRE CCCCCCCCCCCCCCC	26.99	27626673
247	Phosphorylation	EPDDNAKSKQDDKTS CCCCCCCCCCCCCCC	32.89	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WEK_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WEK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WEK_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WEK_DROME	wek	physical	14605208
HEM_DROME	Hem	physical	14605208
DPOA2_DROME	DNApol-alpha73	physical	14605208
DORS_DROME	dl	physical	14605208
TUBE_DROME	tub	genetic	16782008
TOLL_DROME	Tl	genetic	16782008
KPEL_DROME	pll	genetic	16782008
WEK_DROME	wek	physical	16782008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WEK_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.	18327897 [Abstract]