HEM_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM_DROME
• UniProt AC: P55162
• Protein Name: Membrane-associated protein Hem
• Gene Name: Hem
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1126
• Subcellular Localization: Cell membrane ; Single-pass membrane protein ; Cytoplasmic side .
• Protein Description: Plays a role during growth of the oocyte..
• Protein Sequence: MARPIFPNQQKIAEKLIILNDRGLGILTRIYNIKKACGDTKSKPGFLSEKSLESSIKFIVKRFPNIDVKGLNAIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDITLNFELTKYYLDLVVTYVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPLKKLAEEFIPHQRLLTSALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYISLEAMDRWIIFGLLLNHQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSKRIGEVKEAYNTAVQKAALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILWLLRHNDNPPLLKNKGKSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNIRMQSLQMCPEDESIIFSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEHAELARLLDSMVFHTRVVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICSHFQNCTHEMCPEERHHIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSVQSARKKKDKSKSKHFDDIRKPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFAPREYLCQNLEHRFSRDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQALDSHGEKTIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDLNELRALAELVGPYGIKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQDVDRVLQRMTIIGVIICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVASEMASAAGLLCKVDPTLATTLKSKKPEFDEGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNNTHCMAAAINNIFGALFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIVKQSPFLTMDLLESCFPYVLIRNAYHGVYKQEQILGLAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
395	Acetylation	PLLKNKGKSNEDLVD CCCCCCCCCHHHHHH	52.28	21791702
482	Phosphorylation	VEDNELFYFRPFRLD ECCCCCEEECEECCC	16.00	19398577
641	Phosphorylation	AKILSVQSARKKKDK HHHHHHHHHHHCCCC	28.08	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
482	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS
482	Y	Phosphorylation	Kinase	ABL1	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CYFIP_DROME	Sra-1	physical	22036573
RAC1_DROME	Rac1	genetic	10766742
PTP61_DROME	Ptp61F	genetic	19398577
CYFIP_DROME	Sra-1	genetic	15269173
ABL_DROME	Abl	genetic	19398577
ABL_DROME	Abl	genetic	21726548
CYFIP_DROME	Sra-1	physical	15269173

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.