PTP61_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTP61_DROME
• UniProt AC: Q9W0G1
• Protein Name: Tyrosine-protein phosphatase non-receptor type 61F
• Gene Name: Ptp61F
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 548
• Subcellular Localization: Isoform A: Cytoplasm. Endomembrane system. Associates with the membranes of the reticular network and the mitochondria.; Isoform B: Nucleus.
• Protein Description: Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state..
• Protein Sequence: MSEQKTSGSGSAAAARLQIEAEYKDKGPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTLDELPPPLPPRVQSLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPPLPVRAFNDSDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVNANNEKPAVPVDEQHKANGIDPIPGQLPASPENELKRRKRNEYQASLEQKVNDMKRKQRENEDKQLAAKKRRSLLTYIAAGVVVGVICAYAYTKLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	RIVLKRGSVDYINAN CEEEECCCCCEEECC	18.82	19429919
86	Phosphorylation	LKRGSVDYINANLVQ EECCCCCEEECCEEH	8.23	10731132
365	Acetylation	NGAESIGKELSKDAL CCCHHHHHHHCHHHH	54.54	-
482	Phosphorylation	IPGQLPASPENELKR CCCCCCCCCHHHHHH	30.70	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTP61_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTP61_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTP61_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT_DROME	Stat92E	genetic	23339871
MYSA_DROME	Mhc	physical	19398577
MY61F_DROME	Myo61F	physical	19398577
HEM_DROME	Hem	physical	19398577
ABL_DROME	Abl	physical	19398577

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 AND TYR-86, AND MASSSPECTROMETRY.
PubMed: 18327897