STAT_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAT_DROME
• UniProt AC: Q24151
• Protein Name: Signal transducer and transcription activator
• Gene Name: Stat92E
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 761
• Subcellular Localization: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation..
• Protein Description: Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development..
• Protein Sequence: MSLWKRISSHVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIAHMLAAVKELMRVRLVTEEPELTHLLEQVQNAQKNLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNIKFGSCTGRSLTIDNLDFLYEKLQREERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYVNENGLVTMLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVTGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNGDFGMADFDTITNFENF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Sumoylation	ALGMVTPKVELYEVQ CCCCCCCCEEHHHHH	38.69	-
578 (in isoform 3)	Phosphorylation	-	5.57	19429919
682	Phosphorylation	HPSDRNASPVKRDVA CCCCCCCCCCCCCCC	33.50	19429919
704 (in isoform 2)	Phosphorylation	-	9.25	19429919
709	Phosphorylation	PLVLDPVTGYVKSTL CEEECCCCCEEECEE	28.34	29892262
711	Phosphorylation	VLDPVTGYVKSTLHV EECCCCCEEECEEEE	8.71	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
711	Y	Phosphorylation	Kinase	HOP	Q24592	GPS
711	Y	Phosphorylation	Kinase	JAK-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAT_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAT_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDK2_DROME	cdc2c	physical	12586062
HP1_DROME	Su(var)205	physical	18344984
JAK_DROME	hop	genetic	10346822
JAK_DROME	hop	genetic	8650180
JAK_DROME	hop	genetic	9032284
DOME_DROME	dome	genetic	11696329
DECA_DROME	dpp	genetic	16636660
WNTG_DROME	wg	genetic	17079268
DIAP1_DROME	th	genetic	18779571
RAS1_DROME	Ras85D	genetic	14602078
SAYP_DROME	e(y)3	physical	22123744
DOME_DROME	dome	physical	26658615
TAF1_DROME	Taf1	physical	22123744
CI_DROME	ci	physical	26504174

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-711, AND MASSSPECTROMETRY.
PubMed: 18327897

"Identification of a Stat gene that functions in Drosophiladevelopment.";
Yan R., Small S., Desplan C., Dearolf C.R., Darnell J.E. Jr.;
Cell 84:421-430(1996).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), PHOSPHORYLATION AT TYR-711,AND DISRUPTION PHENOTYPE.
PubMed: 8608596