dbPTM

DECA_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DECA_DROME
UniProt AC	P07713
Protein Name	Protein decapentaplegic
Gene Name	dpp
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	588
Subcellular Localization	Secreted . Is internalized by receptor-mediated endocytosis.
Protein Description	Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes..
Protein Sequence	MRAWLLLLAVLATFQTIVRVASTEDISQRFIAAIAPVAAHIPLASASGSGSGRSGSRSVGASTSTALAKAFNPFSEPASFSDSDKSHRSKTNKKPSKSDANRQFNEVHKPRTDQLENSKNKSKQLVNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASASTESHQSSSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	N-linked_Glycosylation	DQLENSKNKSKQLVN HHHHCCCCHHHHHHC	54.37	-
207	Phosphorylation	EQGPSTYSKEALIKD CCCCCCCCHHHHHHC	24.90	27794539
237	Ubiquitination	LLSLFNMKRPPKIDR HHHHCCCCCCCCCCH	63.96	31113955
311	Phosphorylation	RLHFDVKSIPADEKL EEEEECCCCCCCHHH	33.38	22817900
326	Phosphorylation	KAAELQLTRDALSQQ HHHHHHHHHHHHHHH	17.34	22817900
342	N-linked_Glycosylation	VASRSSANRTRYQVL HHCCCCCCCCEEEEE	48.05	-
377	N-linked_Glycosylation	DTKTVRLNSTDTVSL ECCEEECCCCCEEEE	32.09	-
529	N-linked_Glycosylation	FPLADHFNSTNHAVV CCCHHCCCCCCHHHH	44.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DECA_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DECA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DECA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRR_DROME	trr	genetic	14603321
NOTCH_DROME	N	genetic	10495279
HEP_DROME	hep	genetic	10408443
SOG_DROME	sog	genetic	10769238
L2GL_DROME	l(2)gl	genetic	11493541
AFF4_DROME	lilli	genetic	11156991
MAD_DROME	Mad	genetic	7705627
MAD_DROME	Mad	genetic	7768443
MAD_DROME	Mad	genetic	16192307
MAD_DROME	Mad	genetic	8681796
MAD_DROME	Mad	genetic	16887821
IF4A_DROME	eIF-4a	genetic	15972466
EYA_DROME	eya	genetic	10683184
PELO_DROME	pelo	genetic	16280348
MK14B_DROME	p38b	genetic	10022918
SO_DROME	so	genetic	10683184
VG_DROME	vg	genetic	16414040
SMUF1_DROME	lack	genetic	11703946
EGFR_DROME	Egfr	genetic	9649506
60A_DROME	gbb	genetic	16643887
60A_DROME	gbb	genetic	9636086
DALY_DROME	dally	genetic	9374407
UBX_DROME	Ubx	genetic	17050628
OSA_DROME	osa	genetic	9271118
EXOC6_DROME	Sec15	genetic	21811244
HH_DROME	hh	genetic	9630745
TLD_DROME	tld	genetic	7705627
PAX6_DROME	ey	genetic	10683184
SPEN_DROME	spen	genetic	12783785
SCW_DROME	scw	genetic	7705627
INX4_DROME	zpg	genetic	14660550
TSG_DROME	tsg	physical	15797386
SOG_DROME	sog	physical	15797386
SOG_DROME	sog	physical	21839924
DALY_DROME	dally	physical	17055473
SCW_DROME	scw	physical	15797386

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DECA_DROME

Related Literatures of Post-Translational Modification