HEP_DROME - dbPTM
HEP_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HEP_DROME
UniProt AC Q23977
Protein Name Dual specificity mitogen-activated protein kinase kinase hemipterous
Gene Name hep
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1178
Subcellular Localization
Protein Description Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis..
Protein Sequence MSTIEFETIGSRLQSLEAKLQAQNESHDQIVLSGARGPVVSGSVPSARVPPLATSASAATSATHAPSLGAGSVSGSGISIAQRPAPPVPHATPFGSASASSSSSSASAFASAAPATGTFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRPVILPLPTPPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQSIKDNRLRANGDPTLQRATATGSAIGSGAGSLAGSGSGSAGGAVKYGRATTYAGQSPTNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTPTATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSPPSAGIGDLNRLYRKSPFMQRKLSNGSHHPHYKYNDESPKKESMFSSIGQSILRNLTTSPFSQKKHNSTATTIPLPHNNQTLITDAATAAAAAATATTPPNIAATVLTTTPTTTPTWRLPTENSQAYDSCDSSSNATTTTLNLGLSSPSPSLPRKQFPTESPTLQLTSQQQQQPQRLQPGNQSPIVLQRFYHQQNQLREKEAAERYQQQRQQPPVGVTSTNPFHSNYVPPPPSTHSTSSQSSTQSTCSQIAINPASISPSSGSGTGNMAGLGIGSAPASGLGAAGHFGAGGTGEQLQYQPLPIAAEATGTSPTLQSRSPEQQSDYGGNGNMVASKLSKLYARRQLLGQSSSSGASNSSLDGCSREQHDAGWFNTLAGAMKRQFATYVKTQLNSTATSPVASSMDRDQEPVHPQPPAYRSVVNNGSGGKSYYYRTLSAASSSSNTSQSTSPTTEPLPGGGTSSFLRRYASSGPGGSISTPPSPHILAGLDRRHRSPDPPPRYNRGQSPLLLRKNLLELSGQPPGSPLLHRRYVSASPPLPPPRRGSESVPGSPQHFRTRIHYTPEPQRRIYRTIDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
348PhosphorylationISGRLVDSKANTRSA
CCCEEECCCCCCCCC		26.6222817900
352PhosphorylationLVDSKANTRSAGCAA
EECCCCCCCCCCCCH		30.75-
646PhosphorylationDESPKKESMFSSIGQ
CCCCCHHHHHHHHHH		33.7318327897
662PhosphorylationILRNLTTSPFSQKKH
HHHHHCCCCCCCCCC		20.7918327897
786PhosphorylationRLQPGNQSPIVLQRF
CCCCCCCCHHHHHHH		22.1629892262
921PhosphorylationSPTLQSRSPEQQSDY
CCCCCCCCHHHHCCC		37.7322817900
1109PhosphorylationPRYNRGQSPLLLRKN
CCCCCCCCCCHHHHH		21.9725749252
1127PhosphorylationLSGQPPGSPLLHRRY
HHCCCCCCCCCCCCE		20.3921082442
1150PhosphorylationPPRRGSESVPGSPQH
CCCCCCCCCCCCCCC		35.0025749252
1154PhosphorylationGSESVPGSPQHFRTR
CCCCCCCCCCCCCCC		18.4725749252
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HEP_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HEP_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HEP_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
JIP1_DROMEAplip1physical
11912189
ARM_DROMEarmgenetic
12447392
ARM_DROMEarmgenetic
25855961
SGG_DROMEsgggenetic
25855961
DSH_DROMEdshgenetic
12447392
DSH_DROMEdshgenetic
25855961
PROF_DROMEchicgenetic
11703947
WNT4_DROMEWnt4genetic
16369482
WNTG_DROMEwggenetic
12447392
WNTG_DROMEwggenetic
25855961
JRA_DROMEJragenetic
9224721
JRA_DROMEJragenetic
16391236
ENA_DROMEenagenetic
23831567
CADF_DROMEtsrgenetic
23831567
RAC1_DROMERac1genetic
17032066
HDAC1_DROMERpd3genetic
16391236
FGFR2_DROMEbtlgenetic
17032066
FOXO_DROMEfoxogenetic
15820683
AXN_DROMEAxngenetic
25855961
PANG1_DROMEpangenetic
25855961
PANG2_DROMEpangenetic
25855961
PP1B_DROMEflwgenetic
17277363
JNK_DROMEbskgenetic
16002472
JNK_DROMEbskgenetic
16079232
JNK_DROMEbskgenetic
19064708
JNK_DROMEbskgenetic
21986496
JNK_DROMEbskgenetic
25855961
FOSLD_DROMEkaygenetic
16391236
FOSLA_DROMEkaygenetic
16391236
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HEP_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-646; SER-662; SER-1150AND SER-1154, AND MASS SPECTROMETRY.

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