AXN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AXN_DROME
• UniProt AC: Q9V407
• Protein Name: Axin
• Gene Name: Axn
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 745
• Subcellular Localization: Cytoplasm.
• Protein Description: Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3)..
• Protein Sequence: MSGHPSGIRKHDDNECSGPRPPVPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQIIGAIYRFLRKSQLSISDDLRAQIKAIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSGPPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLGSGSVGAGARAPDYPIRLTRDLLIATQKRRLEIRPPGAHGYVYNPSTTNTSYVPNSRVDSERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMANKETNTFQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNERSSASDRAFAEAIREKFALDEDNDQDILDQHVSRVWKDQTPHRSPGTMSPCPPIPSRRRTATHDSGMVSDGAMSLSGHSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKYKDASSRSGSSTASKLEEAKRRLEDEPRRSRRYAQPPMQHLSQQPLASFSSSSSGGSISLPHQPPPLPAKPPETIVVFSFCEEPVPYRIKIPGTQPTLRQFKDYLPRRGHFRFFFKTHCEDPDSPVIQEEIVNDSDILPLFGDKAMGLVKPSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	VADTSKNSSPSYLNW CCCCCCCCCHHHHHH	47.57	19429919
45	Phosphorylation	ADTSKNSSPSYLNWA CCCCCCCCHHHHHHH	27.53	19429919
302	Phosphorylation	QMQEGGGSLGSGSVG EEECCCCCCCCCCCC	32.60	25749252
305	Phosphorylation	EGGGSLGSGSVGAGA CCCCCCCCCCCCCCC	32.94	25749252
307	Phosphorylation	GGSLGSGSVGAGARA CCCCCCCCCCCCCCC	21.05	25749252
428	Phosphorylation	PRTQRLHSNEHRPLK CCCCCCCCCCCCCCC	48.80	22817900
513	Phosphorylation	SRVWKDQTPHRSPGT HHHHHCCCCCCCCCC	31.06	19429919
517	Phosphorylation	KDQTPHRSPGTMSPC HCCCCCCCCCCCCCC	25.34	19429919
520	Phosphorylation	TPHRSPGTMSPCPPI CCCCCCCCCCCCCCC	20.19	19429919
522	Phosphorylation	HRSPGTMSPCPPIPS CCCCCCCCCCCCCCC	24.16	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AXN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AXN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AXN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBF_DROME	Rbf	genetic	24809668
ARM_DROME	arm	genetic	23444354
DSH_DROME	dsh	genetic	12781135
WNTG_DROME	wg	genetic	12781135
SALM_DROME	salm	genetic	23444354
TNKS_DROME	Tnks	genetic	24768997
PYGO_DROME	pygo	genetic	12015286
PANG1_DROME	pan	genetic	11290291
PANG2_DROME	pan	genetic	11290291
PANG1_DROME	pan	genetic	19502486
PANG2_DROME	pan	genetic	19502486
DSH_DROME	dsh	physical	22736244
GNAO_DROME	Galphao	physical	19705439

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-513; SER-517 ANDSER-522, AND MASS SPECTROMETRY.
PubMed: 18327897