| UniProt ID | DSH_DROME | |
|---|---|---|
| UniProt AC | P51140 | |
| Protein Name | Segment polarity protein dishevelled | |
| Gene Name | dsh | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 623 | |
| Subcellular Localization |
Cytoplasm. Nucleus. Membrane Peripheral membrane protein. Associated with the membrane when hyperphosphorylated. |
|
| Protein Description | Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity.. | |
| Protein Sequence | MDADRGGGQETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDSTILPCFNGRVVSWLVSADGTNQSDNCSELPTSECELGMGLTNRKLQQQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPLLQPPPLTYQSASVLSSDLDSTSLFGTESELTLDRDMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSYSSITDSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQALTSHDSIIADIAEPIKERLDQNNLEEIVKAMTKPDSGLEIRDRMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVNEERNPNLLGRGHLHPHQLPHGHGGHALSHADTESITSDIGPLPNPPIYMPYSATYNPSHGYQPIQYGIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSSGSSNRGGGGGGGGGGNNTNDQDVSVFNYVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 231 | Phosphorylation | RRKKRAPSMSRTSSY HHHCCCCCCCCCCCC | 28.53 | 22817900 | |
| 233 | Phosphorylation | KKRAPSMSRTSSYSS HCCCCCCCCCCCCCC | 36.42 | 22817900 | |
| 349 | Phosphorylation | PNPKGYFTIPRTEPV CCCCCCEEECCCCCC | 22.91 | 21082442 | |
| 376 | Phosphorylation | QALTSHDSIIADIAE HHHHCCCCHHHHHHH | 15.52 | 21082442 | |
| 551 | Phosphorylation | GIAERHISSGSSSSD EEEECCCCCCCCCCC | 23.63 | 19429919 | |
| 552 | Phosphorylation | IAERHISSGSSSSDV EEECCCCCCCCCCCC | 41.93 | 19429919 | |
| 554 | Phosphorylation | ERHISSGSSSSDVLT ECCCCCCCCCCCCCC | 29.06 | 19429919 | |
| 555 | Phosphorylation | RHISSGSSSSDVLTS CCCCCCCCCCCCCCC | 37.07 | 19429919 | |
| 556 | Phosphorylation | HISSGSSSSDVLTSK CCCCCCCCCCCCCCC | 32.05 | 19429919 | |
| 557 | Phosphorylation | ISSGSSSSDVLTSKD CCCCCCCCCCCCCCC | 33.42 | 19429919 | |
| 566 | Phosphorylation | VLTSKDISASQSDIT CCCCCCCCCCHHHHH | 31.81 | 23607784 | |
| 568 | Phosphorylation | TSKDISASQSDITSV CCCCCCCCHHHHHHH | 24.35 | 23607784 | |
| 570 | Phosphorylation | KDISASQSDITSVIH CCCCCCHHHHHHHHH | 28.60 | 23607784 | |
| 573 | Phosphorylation | SASQSDITSVIHQAN CCCHHHHHHHHHHHH | 23.18 | 23607784 | |
| 574 | Phosphorylation | ASQSDITSVIHQANQ CCHHHHHHHHHHHHC | 21.29 | 23607784 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DSH_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DSH_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DSH_DROME !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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