WNT5_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNT5_DROME
• UniProt AC: P28466
• Protein Name: Protein Wnt-5
• Gene Name: Wnt5
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1004
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May have a role in limb and CNS development; may be a downstream target of Dll that acts in the specification of these primordia..
• Protein Sequence: MSCYRKRHFLLWLLRAVCMLHLTARGAYATVGLQGVPTWIYLGLKSPFIEFGNQVEQLANSSIPLNMTKDEQANMHQEGLRKLGTFIKPVDLRDSETGFVKADLTKRLVFDRPNNITSRPIHPIQEEMDQKQIILLDEDTDENGLPASLTDEDRKFIVPMALKNISPDPRWAATTPSPSALQPNAKAISTIVPSPLAQVEGDPTSNIDDLKKHILFLHNMTKTNSNFESKFVKFPSLQKDKAKTSGAGGSPPNPKRPQRPIHQYSAPIAPPTPKVPAPDGGGVGGAAYNPGEQPIGGYYQNEELANNQSLLKPTDTDSHPAAGGSSHGQKNPSEPQVILLNETLSTETSIEADRSPSINQPKAGSPARTTKRPPCLRNPESPKCIRQRRREEQQRQRERDEWFRGQSQYMQPRFEPIIQTINNTKRFAVSIEIPDSFKVSSEGSDGELLSRVERSQPSISSSSSSSSSSSRKIMPDYIKVSMENNTSVTDYFKHDVVMTSADVASDREFLIKNMEEHGGAGSANSHHNDTTPTADAYSETIDLNPNNCYSAIGLSNSQKKQCVKHTSVMPAISRGARAAIQECQFQFKNRRWNCSTTNDETVFGPMTSLAAPEMAFIHALAAATVTSFIARACRDGQLASCSCSRGSRPKQLHDDWKWGGCGDNLEFAYKFATDFIDSREKETNRETRGVKRKREEINKNRMHSDDTNAFNIGIKRNKNVDAKNDTSLVVRNVRKSTEAENSHILNENFDQHLLELEQRITKEILTSKIDEEEMIKLQEKIKQEIVNTKFFKGEQQPRKKKRKNQRAAADAPAYPRNGIKESYKDGGILPRSTATVKARSLMNLHNNEAGRRAVIKKARITCKCHGVSGSCSLITCWQQLSSIREIGDYLREKYEGATKVKINKRGRLQIKDLQFKVPTAHDLIYLDESPDWCRNSYALHWPGTHGRVCHKNSSGLESCAILCCGRGYNTKNIIVNERCNCKFHWCCQVKCEVCTKVLEEHTCK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	N-linked_Glycosylation	NQVEQLANSSIPLNM HHHHHHHHCCCCCCC	44.90	-
66	N-linked_Glycosylation	ANSSIPLNMTKDEQA HHCCCCCCCCHHHHH	30.62	-
115	N-linked_Glycosylation	LVFDRPNNITSRPIH EECCCCCCCCCCCCC	41.41	-
219	N-linked_Glycosylation	KHILFLHNMTKTNSN HHHHHHCCCCCCCCC	41.80	-
307	N-linked_Glycosylation	QNEELANNQSLLKPT CCHHHHCCCCCCCCC	27.49	-
341	N-linked_Glycosylation	EPQVILLNETLSTET CCCEEEECCCCCCCC	36.44	-
422	N-linked_Glycosylation	EPIIQTINNTKRFAV HHHHHHCCCCCCEEE	54.21	-
484	N-linked_Glycosylation	YIKVSMENNTSVTDY EEEEECCCCCCCCHH	48.73	-
485	N-linked_Glycosylation	IKVSMENNTSVTDYF EEEECCCCCCCCHHH	22.03	-
528	N-linked_Glycosylation	GSANSHHNDTTPTAD CCCCCCCCCCCCCCC	42.79	-
593	N-linked_Glycosylation	QFKNRRWNCSTTNDE EECCCCCCCCCCCCC	14.19	-
724	N-linked_Glycosylation	NKNVDAKNDTSLVVR CCCCCCCCCCCEEEE	60.56	-
868	O-palmitoleoylation	TCKCHGVSGSCSLIT EEEECCCCCCCHHHH	29.58	-
952	N-linked_Glycosylation	HGRVCHKNSSGLESC CCCCCCCCCCCCCCE	20.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNT5_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNT5_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WNT5_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RYK1_DROME	drl	physical	12660735
DSH_DROME	dsh	genetic	17032066
DSH_DROME	dsh	genetic	26180192
PORCN_DROME	por	genetic	15282154
WNT4_DROME	Wnt4	genetic	17507403
CADN_DROME	CadN	genetic	21117153
UZIP_DROME	uzip	genetic	21117153
RAC1_DROME	Rac1	genetic	26180192
FRIZ2_DROME	fz2	genetic	17032066
RYK1_DROME	drl	genetic	22403643
RYK1_DROME	drl	genetic	25981040
RYK1_DROME	drl	genetic	12660735
RYK1_DROME	drl	genetic	25378162
FRIZ_DROME	fz	genetic	17032066

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.