| UniProt ID | RYK1_DROME | |
|---|---|---|
| UniProt AC | Q27324 | |
| Protein Name | Tyrosine-protein kinase Drl | |
| Gene Name | drl | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 610 | |
| Subcellular Localization |
Cell membrane Single-pass membrane protein . |
|
| Protein Description | Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non-vital for development. May be part of a signal transduction cascade involved in learning and possibly memory.. | |
| Protein Sequence | MAPNLLTIGLLLTLIASGQAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISDVTFTWQSLVDHPLPYSINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTYNDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVLYAATGSVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 63 | N-linked_Glycosylation | FAVPVPANISDVTFT EEEECCCCCCCCEEE | 28.38 | - | |
| 99 | N-linked_Glycosylation | VLPRPILNISRIGDV CCCCCEEEEECCCCC | 30.80 | - | |
| 143 | N-linked_Glycosylation | ILDRATNNNTNLIFK EEEECCCCCCCEEEE | 52.96 | - | |
| 498 | Phosphorylation | RDLFPGDYNSLGDGE CCCCCCCCCCCCCCC | 16.74 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RYK1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RYK1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RYK1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MIRO_DROME | Miro | physical | 14605208 | |
| WNT5_DROME | Wnt5 | physical | 12660735 | |
| TYDP1_DROME | gkt | physical | 22036573 | |
| TERA_DROME | TER94 | physical | 22036573 | |
| WNT5_DROME | Wnt5 | genetic | 17934456 | |
| WNT5_DROME | Wnt5 | genetic | 19369566 | |
| WNT5_DROME | Wnt5 | genetic | 25378162 | |
| WNT5_DROME | Wnt5 | genetic | 12660735 | |
| RYK2_DROME | dnt | genetic | 9858720 | |
| CAS_DROME | cas | genetic | 11335107 | |
| FRIZ_DROME | fz | genetic | 17507403 | |
| WNT5_DROME | Wnt5 | physical | 25981040 | |
| RYK1_DROME | drl | physical | 23979591 | |
| SRC64_DROME | Src64B | physical | 23979591 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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