dbPTM

RYK2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RYK2_DROME
UniProt AC	Q9V422
Protein Name	Tyrosine-protein kinase Dnt
Gene Name	dnt
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	584
Subcellular Localization	Cell membrane Single-pass membrane protein .
Protein Description	May play an essential role in neuronal pathway recognition and ventral muscle attachment site selection..
Protein Sequence	MESVNKCGKSASTRNCTVKMSRKMWVLSLLALAALQLHSGSEVAAHLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNFIVPVPANVKDISFTWQSLAGRGLPYSINVVSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
124	N-linked_Glycosylation	VLPRPAINVSHSGEI CCCCCCEECCCCCCC	31.20	-
163	N-linked_Glycosylation	VSLEVVLNRSLNNVT EEEEEHHHCCCCCCC	21.64	-
168	N-linked_Glycosylation	VLNRSLNNVTHLVFR HHHCCCCCCCEEHHC	45.41	-
183	N-linked_Glycosylation	RKKICLMNDSAEDLS CCCEEEECCCHHHHH	27.43	-
472	Phosphorylation	RDLFPSDYNCLGDSE CCCCCCCCCCCCCCC	16.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RYK2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RYK2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RYK2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
VND_DROME	vnd	physical	14605208
RYK1_DROME	drl	physical	23979591

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RYK2_DROME

Related Literatures of Post-Translational Modification