TYDP1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TYDP1_DROME
• UniProt AC: Q9VQM4
• Protein Name: Probable tyrosyl-DNA phosphodiesterase
• Gene Name: gkt
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 580
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity). Required for normal polarization of epidermal cells, correct subcellular location of the Crb complex to the apical lateral membrane, and for normal neuronal development during embryonic development..
• Protein Sequence: MKECPYGEKCYRKNPIHFGEFSHAHLDAIYAKGNESGDYEIPANYSSEMIHTQLKLLEKLFPKQATNKEQEAHSSSSKPAVTAPVASGSSSSGSLDTNPSGSSASGPAASQDTSNLAKKQKLNAKNIRDYIPVVIEKGGMAKKLERAAPYNMFLTAITDSKPTHSEPLSITLQEILDESLGEIESTVQINFMVDIGWLLGHYYFAGILDKPLLLLYGDESPELLSIGKFKQQVTAIRVKMPTPFATSHTKMMFLGYSDGSMRVVISTANLYEDDWHNRTQGLWISPKLPALPVDADTGAGESLTGFKQDLMLYLVEYKISQLQPWIARIRNSDFSAINVFFLGSVPGGHREGSVRGHPWGHARLASLLAKHAAPIDDRIPVVCQSSSIGSLGANVQAWIQQDFVNSLKKDSTPVGKLRQMPPFKMIYPSYGNVAGSHDGMLGGGCLPYGKNTNDKQPWLKDYLQQWKSSDRFRSRAMPHIKSYTRFNLEDQSVYWFVLTSANLSKAAWGCFNKNSNIQPCLRIANYEAGVLFLPRFVTGEDTFPLGNNRDGVPAFPLPYDVPLTPYAPDDKPFLMDYLQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Oops, there are no PTM records of TYDP1_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TYDP1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TYDP1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TYDP1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_DROME	TER94	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.