FRIZ2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRIZ2_DROME
• UniProt AC: Q9VVX3
• Protein Name: Frizzled-2
• Gene Name: fz2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 694
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles..
• Protein Sequence: MRHNRLKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVASTSHHHLHHHVLKQPAASHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	N-linked_Glycosylation	MCRGIGYNMTSFPNE ECCCCCCCCCCCCCC	23.26	-
288	N-linked_Glycosylation	HPHHWYMNLTVQRIA CCCCCEECCCHHHHH	19.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRIZ2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRIZ2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRIZ2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WIF1_DROME	shf	genetic	22383891
WNTG_DROME	wg	genetic	9671581
WNTG_DROME	wg	genetic	9875856
WNTG_DROME	wg	genetic	10996794
ITBN_DROME	Itgbetanu	genetic	23054837
GNAO_DROME	Galphao	genetic	16617104
LAMA_DROME	LanA	genetic	23054837
DALY_DROME	dally	genetic	10421372
HID_DROME	W	genetic	16369482
DCO_DROME	dco	genetic	16824922
FRIZ_DROME	fz	genetic	10556068
FRIZ_DROME	fz	genetic	9671581
MARF_DROME	Marf	physical	27451905
DSH_DROME	dsh	physical	14636582
WNTG_DROME	wg	physical	22203956
WNTG_DROME	wg	physical	22285813
WNTG_DROME	wg	physical	8717036
IMA_DROME	Pen	physical	20601947
FRIZ2_DROME	fz2	physical	17960137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.