| UniProt ID | GNAO_DROME | |
|---|---|---|
| UniProt AC | P16378 | |
| Protein Name | G protein alpha o subunit | |
| Gene Name | Galphao | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 354 | |
| Subcellular Localization | ||
| Protein Description | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphai and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord.. | |
| Protein Sequence | MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDFKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNKSTSKEIYCHMTCATDTNNIQFVFDAVTDVIIANNLRGCGLY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Myristoylation | ------MGCAQSAEE ------CCCCCCHHH | 18.57 | - | |
| 3 | S-palmitoylation | -----MGCAQSAEER -----CCCCCCHHHH | 2.77 | - | |
| 59 | Phosphorylation | QMKIIHESGFTAEDF CCEEHHHCCCCHHHH | 25.66 | 27794539 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GNAO_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GNAO_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GNAO_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KNRL_DROME | knrl | physical | 14605208 | |
| VA0D1_DROME | VhaAC39-1 | physical | 14605208 | |
| RS3_DROME | RpS3 | physical | 14605208 | |
| PIP1_DROME | Plc21C | genetic | 21145008 | |
| GBG1_DROME | Ggamma1 | genetic | 16617104 | |
| FRIZ2_DROME | fz2 | genetic | 16617104 | |
| FRIZ_DROME | fz | genetic | 15652486 | |
| FRIZ_DROME | fz | genetic | 16617104 | |
| HSP7C_DROME | Hsc70-3 | physical | 20808795 | |
| GBB1_DROME | Gbeta13F | physical | 20808795 | |
| TBB1_DROME | betaTub56D | physical | 20808795 | |
| MTH5_DROME | mthl5 | physical | 26994946 | |
| RGS_DROME | loco | physical | 24560274 | |
| RGS_DROME | loco | physical | 19570914 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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