dbPTM

UZIP_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UZIP_DROME
UniProt AC	P10379
Protein Name	Protein unzipped
Gene Name	uzip
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	488
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Required for normal axon patterning during neurogenesis..
Protein Sequence	MTSNSCLISLGLLLVLIQILAPAKAAEHSVFTHKNASSVLGQLVTSSTLVWESYDPKDATQLQFAVEGGKYVTEDEHYPMYVCRVPIDGIQVSGHTEKILQRHVCLAAHYKHGKYDNFDVLMNKGHLGKVGWRHWRKFDAGVPVGAIRIGDDSYIGRHRAPSQPNKDGVVTHWGADFNLGHLEPVGLGKIRVIEAEREKYYDDGEVLVETEPFRYELRDIKLDRLRTDIQENMTELVTRKLENLEDKYSTVETILSYTFNYNQYWGSHEGVARGLPTKIFEKDEAVPAEINWALKHTEKRSENKAVHTKLWPGTAINVTLRGNYVTLEAPYSGKLFAFYYGSDESVSRKISAEVRKSYLKEVKLEFSPVYWIENGTLVPTTTTTTTTSTSTTTHATTTSTNEPTPINEPPLVHMKDNGVQHSGPDTLEKTLHDSPSSNELNSHEAPENMSSDPGKDVALAGFGVNAAGSTFIAGSALLTLLLTIFLSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	N-linked_Glycosylation	HSVFTHKNASSVLGQ CCCCCCCCHHHHHHH	37.13	-
232	N-linked_Glycosylation	LRTDIQENMTELVTR HHHHHHHHHHHHHHH	26.71	17893096
317	N-linked_Glycosylation	LWPGTAINVTLRGNY ECCCCEEEEEEECCE	20.46	-
374	N-linked_Glycosylation	SPVYWIENGTLVPTT ECEEEEECCEEECEE	39.35	-
436	Phosphorylation	KTLHDSPSSNELNSH HHHCCCCCCCCCCCC	50.15	27794539
437	Phosphorylation	TLHDSPSSNELNSHE HHCCCCCCCCCCCCC	37.39	27794539
442	Phosphorylation	PSSNELNSHEAPENM CCCCCCCCCCCCCCC	35.02	27794539
448	N-linked_Glycosylation	NSHEAPENMSSDPGK CCCCCCCCCCCCCCC	34.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UZIP_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UZIP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UZIP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of UZIP_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UZIP_DROME

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232, AND MASSSPECTROMETRY.	19349973 [Abstract]
"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster."; Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.; Glycobiology 17:1388-1403(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232, AND MASSSPECTROMETRY.	17893096 [Abstract]