| UniProt ID | MED16_DROME | |
|---|---|---|
| UniProt AC | Q9W278 | |
| Protein Name | Mediator of RNA polymerase II transcription subunit 16 | |
| Gene Name | MED16 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 818 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. Required for transcriptional activation in response to lipopolysacchardie (LPS).. | |
| Protein Sequence | MTILYKVEGKEFSKDSVFPHKKVLCSVSARNIVAFSALQSAIFPASHGGDAGDGSLPGAGLAVGASNSHVYVCDIVTPWEYYKVCSSKSLISVLQWSPNGEQLLLGYVGGRVEIWQPRNQSINLWVLQYYATVPSEDIIEAQFFQNGKGVIFNALKKDHTYYAEKFERVEQQRPTLSGFGGVASEGCVLLTSSGLLAAFSLPAIQKTSAAGADGPAHEVVELTPALHSIGISRSFIEHCSMTPSPSGALNIAFSCGWQQQLVQCFKVSLSLEGELGLEQHLAIKSESQTSIFLGPLDGRRISHLKWTRIANEDVIFIAYACPDGAGSQLEQWTLTRRHQSVHALLQGGGGANNKPNEFVQSESWEQVGKVQLNASLADISVTRLSVSTPDSCQVYAILQDNSVQVLEPNSMKQLNHTQFDRLSDASGAVKFVSGDLTPSSQILLIFDSHAQLYAMQAPLPKQGGSGLLLLEYCIVTGCDASDVLLLNLGNLEALVEKLTDNFTRQPSFVRHFYYANFLALKSNICRMQQQEFDNLIILHAISTTFKSLLRPSDLGFQDKGPADNLAIKLAESIPDVDTVMLNLDAKDFTVEPVMLQSLQQLIQWVTDLALNMLHRLPEEVMKTKLSGKRPSYDISRDIVAISSLRELLVMIRIWGLLNTQCLPVYTKTMDNIDVLVILFRLLTRLAQNPAEPDEMLLDECSLLSKQLLIPQPTKFNPTTLLSAQGFAAVKSGQLQFTSMEEPTCLQDMETEEVVFASSVKDGVSNLQLGARPSHIRRCARCGFVFVNNASKVAKTSALKAWFSKWLHCHCGGFWKQVH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of MED16_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MED16_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MED16_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MED16_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MED17_DROME | MED17 | physical | 22036573 | |
| CPSF6_DROME | CG7185 | physical | 22036573 | |
| MED14_DROME | MED14 | physical | 22036573 | |
| MED11_DROME | MED11 | physical | 22036573 | |
| MED23_DROME | MED23 | physical | 22036573 | |
| MED4_DROME | MED4 | physical | 22036573 | |
| MED7_DROME | MED7 | physical | 22036573 | |
| MED30_DROME | MED30 | physical | 22036573 | |
| MED10_DROME | MED10 | physical | 22036573 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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