CPSF6_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPSF6_DROME
• UniProt AC: Q9VSH4
• Protein Name: Cleavage and polyadenylation specificity factor subunit CG7185
• Gene Name: CG7185
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 652
• Subcellular Localization: Nucleus.
• Protein Description: May play a role in pre-mRNA 3'-processing..
• Protein Sequence: MADVVLDLYAEDLDKDFAGQAQDEFGGDGVDLYDDIGGPTESAASGGGGGGTPSADGAAGPGSGEPGERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGVSDLQEVKFFENRANGQSKGFSVISLGSESSLRAVLDQLPKKEMHGQAPVVTYPSKQALTQFESLQKTRPVPPPQQNGPPRGPAPPSMGGGPMPTGHPGGPQGGGPPGHPPRGMNSIMQPGQYRPQHMSQVPQVGGPNSGPPRMQPPMHPQGGLMGNQQPPPRYPSAQGQWPGQRPGGPRPGPPNGPPQRPMFQGGPMGMPVRGPAGPDWRRPPMHGGFPPQGPPRGLPPAPGPGGPHGAPAPHVNPAFFNQPGGPAQHPGMGGPPHGAPGPQPGMNMPPQQGMNMTPQHGPPPQFAQHGPRGPWPPPQGKPPGPFPDPQQMGPQLTEVEFEEVMSRNRTVSSSAIARAVSDAAAGEYSSAIETLVTAISLIKQSKVAHDERCKILISSLQDTLHGIEAKSYNRRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGSYRERSRSRERERQAPDHYRDDSRSVRPRKSPEPVVAEAAEAPSSKRYYEDRERYRSSDRERRDRDRDRDRERERDRDRREEHRSRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	GPTESAASGGGGGGT CCCCCCCCCCCCCCC	37.37	19429919
52	Phosphorylation	SGGGGGGTPSADGAA CCCCCCCCCCCCCCC	19.83	19429919
54	Phosphorylation	GGGGGTPSADGAAGP CCCCCCCCCCCCCCC	38.54	19429919
84	Phosphorylation	VYHQSSGSLTPTMNR CCCCCCCCCCCCCCC	30.90	19429919
86	Phosphorylation	HQSSGSLTPTMNRRY CCCCCCCCCCCCCEE	20.57	19429919
88	Phosphorylation	SSGSLTPTMNRRYQL CCCCCCCCCCCEEEE	23.11	19429919
468	Phosphorylation	SAIARAVSDAAAGEY HHHHHHHHHHHHCCH	22.13	23607784
475	Phosphorylation	SDAAAGEYSSAIETL HHHHHCCHHHHHHHH	13.65	23607784
476	Phosphorylation	DAAAGEYSSAIETLV HHHHCCHHHHHHHHH	14.70	23607784
477	Phosphorylation	AAAGEYSSAIETLVT HHHCCHHHHHHHHHH	32.15	23607784
481	Phosphorylation	EYSSAIETLVTAISL CHHHHHHHHHHHHHH	22.03	23607784
484	Phosphorylation	SAIETLVTAISLIKQ HHHHHHHHHHHHHHH	22.76	23607784
487	Phosphorylation	ETLVTAISLIKQSKV HHHHHHHHHHHHHHC	22.90	23607784
492	Phosphorylation	AISLIKQSKVAHDER HHHHHHHHHCCCHHH	24.89	23607784
541	Phosphorylation	SRQRRERSTSRYRER HHHHHHHHHHHHHHH	26.44	25749252
542	Phosphorylation	RQRRERSTSRYRERS HHHHHHHHHHHHHHH	24.36	25749252
543	Phosphorylation	QRRERSTSRYRERSR HHHHHHHHHHHHHHH	28.67	25749252
596	Phosphorylation	RSVRPRKSPEPVVAE CCCCCCCCCCCHHHH	35.46	21082442
622	Phosphorylation	EDRERYRSSDRERRD HHHHHHHHCHHHHHH	27.88	22817900
623	Phosphorylation	DRERYRSSDRERRDR HHHHHHHCHHHHHHH	31.52	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPSF6_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPSF6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPSF6_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED17_DROME	MED17	physical	22036573
MED11_DROME	MED11	physical	22036573
MED10_DROME	MED10	physical	22036573
MED27_DROME	MED27	physical	22036573
MED7_DROME	MED7	physical	22036573
MED25_DROME	MED25	physical	22036573
YAP1_DROME	yki	physical	24114784

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-596, AND MASSSPECTROMETRY.
PubMed: 17372656