SQH_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SQH_DROME
• UniProt AC: P40423
• Protein Name: Myosin regulatory light chain sqh
• Gene Name: sqh
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 174
• Protein Description: Required for cytokinesis, could regulate contractile ring function..
• Protein Sequence: MSSRKTAGRRATTKKRAQRATSNVFAMFDQAQIAEFKEAFNMIDQNRDGFVEKEDLHDMLASLGKNPTDDYLDGMMNEAPGPINFTMFLTLFGERLQGTDPEDVIKNAFGCFDEENMGVLPEDRLRELLTTMGDRFTDEDVDEMYREAPIKNGLFDYLEFTRILKHGAKDKDEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	KKRAQRATSNVFAMF HHHHHHHHHHHHHHC	24.03	19429919
22	Phosphorylation	KRAQRATSNVFAMFD HHHHHHHHHHHHHCC	29.97	9412474
157	Phosphorylation	IKNGLFDYLEFTRIL CCCCCCHHHHHHHHH	10.78	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
22	S	Phosphorylation	Kinase	PAK-SUBFAMILY	-	GPS
22	S	Phosphorylation	Kinase	PAK	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SQH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SQH_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PICO_DROME	Picot	physical	22036573
ROP_DROME	Rop	physical	22036573
OVO_DROME	ovo	genetic	17656094
PKN_DROME	Pkn	genetic	25131196
MYSN_DROME	zip	genetic	20553709
PATJ_DROME	Patj	physical	23128243
PP1B_DROME	flw	physical	15269282

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-21 AND SER-22, AND MASSSPECTROMETRY.
PubMed: 18327897

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-21 AND SER-22, AND MASSSPECTROMETRY.
PubMed: 17372656