ROP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ROP_DROME
• UniProt AC: Q07327
• Protein Name: Protein ROP
• Gene Name: Rop
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 597
• Subcellular Localization: Cytoplasm, cytosol . Membrane ; Peripheral membrane protein . Soluble or bound to membranes.
• Protein Description: May be a component of one of the vesicle trafficking pathways. May interact functionally with Ras2 protein..
• Protein Sequence: MALKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGITLVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLCKSCAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKHIERIAEQIATLCATLGEYPNVRYRSDWDRNIDLAASVQQKLDAYKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELTLQAMAYDLLPIVNDVYRYTPGPNQPDKEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFTDSKRMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTDAEGEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQDMVRNLSCLGINVIADSRKKQYSVPRKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLEGRAQNTNYHAPTSARYGHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVRNWEVLVGSSHILSPEIFLSDLGSLSKED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
332	Phosphorylation	MGSADKSSMRDLSQM CCCCCHHHHHHHHHH	24.47	21082442
517	Phosphorylation	LEGRAQNTNYHAPTS CCCCCCCCCCCCCCC	25.69	19429919
519	Phosphorylation	GRAQNTNYHAPTSAR CCCCCCCCCCCCCCC	9.41	19429919
523	Phosphorylation	NTNYHAPTSARYGHW CCCCCCCCCCCCCCC	35.48	19429919
524	Phosphorylation	TNYHAPTSARYGHWH CCCCCCCCCCCCCCC	15.08	19429919
527	Phosphorylation	HAPTSARYGHWHKDK CCCCCCCCCCCCCCC	17.04	18281928

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ROP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ROP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ROP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DISC_DROME	disco	physical	14605208
PRS4_DROME	Rpt2	physical	22036573
DYN_DROME	shi	genetic	26483382
EXOC3_DROME	Sec6	physical	26483382
EXOC6_DROME	Sec15	physical	26483382

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.