MED15_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED15_DROME
• UniProt AC: Q9Y149
• Protein Name: Mediator of RNA polymerase II transcription subunit 15
• Gene Name: MED15
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 749
• Subcellular Localization: Nucleus.
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes..
• Protein Sequence: MTEDWQSQKFRQNVISKIHDLLPPNAQDQTKNAGVMENHIFRKSRTKDEYLGLVAKLFMHYKDMSRKSQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQMMPMGAGGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMSNIRGQMPMGAGGAGAQQMMQVQQMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMVGPGPNSGPAVGGAGGPNAAPGAGGPGPNQMQGGPMNVNAMQQMPPMQQIQQNQLGMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPQGPHNVVGGPAGQQQVGGAGLPPNAVQQGGMNPMGGMGVNMPPNLQQKPNMPMGQAGQMFPGNRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQQQQQQLVVGNQTPTQQPPTPQMPTPNMIPSPALVPQSSPQMMQMQNSQRNIRQQSPSASINTPGQVTGNSPFNPQEEALYREKYKQLTKYIEPLKRMLAKISNDGTNVEKMTKMSKLLEILCNPTQRVPLETLLKCEKALEKMDLISYSGQQFGKSSNPLLEVINTTLQSPVANHTLYRTFRPTLELLFGTDITAPVPAKRPRVEEKSTSFEQEVPHVLQGEIARLDTKFKVKLDTTSQINNKAIRLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLAEQEYSATPFLQTVQQALIARISKLPKNYSLSHLLDTWEMAVRQACSPQSKPRAVCELSTLLGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
461	Phosphorylation	QRNIRQQSPSASINT HHHHHHHCCCCCCCC	16.69	30478224
576	Phosphorylation	VINTTLQSPVANHTL HHHHHCCCCCCCCHH	25.18	22817900
582	Phosphorylation	QSPVANHTLYRTFRP CCCCCCCHHHHHHHC	25.87	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED15_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED15_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED15_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED14_DROME	MED14	physical	22036573
MED17_DROME	MED17	physical	22036573
CPSF6_DROME	CG7185	physical	22036573
MED7_DROME	MED7	physical	22036573
MED30_DROME	MED30	physical	22036573
MED4_DROME	MED4	physical	22036573
MED11_DROME	MED11	physical	22036573
MED8_DROME	MED8	physical	22036573
MED16_DROME	MED16	physical	22036573
MED27_DROME	MED27	physical	22036573
MED23_DROME	MED23	physical	22036573
MED10_DROME	MED10	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.