| UniProt ID | MED8_DROME | |
|---|---|---|
| UniProt AC | A1ZBT5 | |
| Protein Name | Mediator of RNA polymerase II transcription subunit 8 | |
| Gene Name | MED8 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 252 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA and MtnB genes.. | |
| Protein Sequence | MQRDEKLFELTLDTVLQRLNDLKLAVLSMIQKLELEYETINWPTFLDNFAIISSHLTGLTKILAKEQCPPLRNRTVLPLLVSMDRDDTLINITEGRVPVFSHDIVPDYLRTRPDPITEQKMLQNEQKAANLTNDAAMKQVTQYNKVVSHVLDMVSKAREEWEIESSSRTGIQQTSSMADTQLLVAAVGMGKGLKLTNYGPGPGMMVPPSIRAPSPMGGPAMSPGNVQQQLGKAPSAVKTNIKSANQVHPFSR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of MED8_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MED8_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MED8_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MED8_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CSN3_DROME | CSN3 | physical | 14605208 | |
| DMDD_DROME | Dys | physical | 14605208 | |
| DMDE_DROME | Dys | physical | 14605208 | |
| DMDB_DROME | Dys | physical | 14605208 | |
| DMDA_DROME | Dys | physical | 14605208 | |
| DORS_DROME | dl | physical | 14605208 | |
| CPSF6_DROME | CG7185 | physical | 22036573 | |
| MED17_DROME | MED17 | physical | 22036573 | |
| MED27_DROME | MED27 | physical | 22036573 | |
| MED11_DROME | MED11 | physical | 22036573 | |
| MED14_DROME | MED14 | physical | 22036573 | |
| MED30_DROME | MED30 | physical | 22036573 | |
| MED4_DROME | MED4 | physical | 22036573 | |
| MED7_DROME | MED7 | physical | 22036573 | |
| MED23_DROME | MED23 | physical | 22036573 | |
| Y1505_DROME | CG11505 | physical | 22036573 | |
| MED10_DROME | MED10 | physical | 22036573 | |
| MED16_DROME | MED16 | physical | 22036573 | |
| MED25_DROME | MED25 | physical | 22036573 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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