DMDA_DROME - dbPTM
DMDA_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DMDA_DROME
UniProt AC Q9VDW6
Protein Name Dystrophin, isoforms A/C/F/G/H
Gene Name Dys
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 3598
Subcellular Localization Cell membrane, sarcolemma
Peripheral membrane protein
Cytoplasmic side . Cytoplasm, cytoskeleton . Isoform A is localized to both the postsynaptic region of the NMJ and to the extrasynaptic regions, where it colocalizes with actin.
Protein Description Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. Both det and Dg are required for maintenance of early dpp signaling in the presumptive crossvein. Isoform A is not required to maintain muscle integrity, but plays a role in neuromuscular homeostasis by regulating neurotransmitter release. May play a role in anchoring the cytoskeleton to the plasma membrane..
Protein Sequence MEPGILIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKPEKGRMRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQYTEPHGLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQHALKRLHLAFDLAHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQQRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNERGGELLLQMDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQLGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWLDKIQEIGNELIDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEKCIVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISELIDEHTRNGKVGAANRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNTVQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIEKLQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGESPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLLRPSAENTSTPFLRVEKRRISFDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKNPNPFLSKVLESLSSPVDDSNVTLKSPISEEQPQNLDDRVREFDKQAKQMIYKLKLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFREVQQARSKTSGSGAPAPPLDSVNIEELVTKGLRRINVLIEKTVDLKSSTDLEKRMEDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIAHADSIELSLTELRNGPRISNGKERPDASSAATMSCRSEYNNEPSGTGALAGSFDKSVLQISDWLTWEQNMIKIQSVLVDDGDAVRLAIEKQEKVLRELKMKKPQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHCSADLDYMRCCLKVTRLREHWDETSQCVLQRAAQLKNMLSDSQRFEAKRLELEKWLARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIKKMTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMDQFLAFLSETETLCENAESDIERNPLMFKDLQSEIETHRVVYDRLDGTGRKLLGSLTSQEDAVMLQRRLDEMNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTELSTLGLGPVRGDAVSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYIANEAAVSDTSDTEANHDSDSRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQFQKILEDLSSRVALAEQTKTSWLPPSSVGEANEQMQQLQRLRDKMTTASALLDDCNEQQSFFTANQVLVPTPCLSKLEDLNTRMKLLQIAMDERQKVLCQAGAQQTHENGDDGRTTSNSGTIGPLPNLGQSVKPPWERATTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTIDKIDLTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTDRRADQRRLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCLEQAGISQEAIDGNQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCFNFDMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFKSRKYFKKHPRVGYLPVQSVLEGDALESPAPSPQHTTHQLQNDMHSRLEMYASRLAQVEYGGTGSNSTPDSDDEHQLIAQYCQALPGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEEENANLQAEYQQLCSKEQSGMPEDSNGMQHSSSSMTGLSGQGEQGQDMMAEAKLLRQHKGRLEARMQILEDHNRQLEAQLQRLRQLLDEPNGGGSSATSSGLPSAPGSALNSKPNTLQTRSVTASQLNTDSPAKMNQQNGHYEHNSKGIMLPGMNSEIQQQHAQLASLAAKHHQHQLSGALNALHQQQQQQLQQQPPQQQRSMMTGNGGMDISGGMQTSGGYLGDDGRPPPPPHSSLMQQQHQQHLNENSSGLVTVITEQELESINDDLEDSSSSNTTNTTTTTTTTATTEKTCVELQK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
634PhosphorylationNFGRDRASYDDSRVV
CCCCCCCCCCCCCCC		29.9519429919
710PhosphorylationLQQLQRQSLRQQCEL
HHHHHHHHHHHHHHH		27.9227626673
1740PhosphorylationTKRKAPSSPAQVVEI
CCCCCCCCCCCEEEE		24.1627626673
1817PhosphorylationQGKEMRRSKSKHSLN
HHHHCHHCCCCCCCC		30.8025749252
1819PhosphorylationKEMRRSKSKHSLNET
HHCHHCCCCCCCCCC		36.5319429919
1822PhosphorylationRRSKSKHSLNETPLP
HHCCCCCCCCCCCCC		36.3019429919
1826PhosphorylationSKHSLNETPLPKVSD
CCCCCCCCCCCCCCC		29.1119429919
1832PhosphorylationETPLPKVSDNDEDSA
CCCCCCCCCCCCCHH		36.5018327897
1838PhosphorylationVSDNDEDSAEQEEDL
CCCCCCCHHHHHHHH		31.4918327897
1866PhosphorylationRVEKRRISFDEKRKR
EEECCCCCHHHHHHH		25.4922668510
1884PhosphorylationERDILRDSEEEEPKT
HHHHCCCCCCCCCCC		40.2419429919
1891PhosphorylationSEEEEPKTPDTPRAA
CCCCCCCCCCCCCHH		36.7919429919
1943PhosphorylationDAEPLVFSDDEDIPR
CCCCCCCCCCCCCCC		36.3519429919
1986PhosphorylationFLSKVLESLSSPVDD
HHHHHHHHCCCCCCC		29.4119429919
1988PhosphorylationSKVLESLSSPVDDSN
HHHHHHCCCCCCCCC		41.7019429919
1989PhosphorylationKVLESLSSPVDDSNV
HHHHHCCCCCCCCCC		33.9519429919
3198PhosphorylationVGYLPVQSVLEGDAL
CCEECCCCHHCCCCC		28.9821082442
3207PhosphorylationLEGDALESPAPSPQH
HCCCCCCCCCCCCCC		27.4911018515
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DMDA_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DMDA_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DMDA_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCP2_DROMEGrip84physical
14605208
VPS72_DROMEYL-1physical
14605208
IMA_DROMEPenphysical
14605208
CCNC_DROMECycCphysical
14605208
EI3F1_DROMECG9769physical
14605208
DECA_DROMEdppgenetic
9012523
DECA_DROMEdppgenetic
18545683
WNTG_DROMEwggenetic
18545683
GBLP_DROMERack1genetic
21256839
SEM1A_DROMESema-1agenetic
18545683
GCM_DROMEgcmgenetic
18545683
DEL_DROMEdelgenetic
18545683
WUN_DROMEwungenetic
18545683
WUN_DROMEwungenetic
23154413
STAN_DROMEstangenetic
18545683
CALM_DROMECamgenetic
21256839
CALM_DROMECamgenetic
18545683
ROR2_DROMENrkgenetic
18545683
SLIT_DROMEsligenetic
18545683
LIS1_DROMELis-1genetic
18545683
KINH_DROMEKhcgenetic
18545683
SEM2A_DROMESema-2agenetic
18545683
MBL_DROMEmblgenetic
21256839
MBL_DROMEmblgenetic
18545683
ELF1_DROMEgrhgenetic
18545683
SDC_DROMESdcgenetic
18545683
GIL_DROMEaosgenetic
18545683
DL_DROMEDlgenetic
18545683
DCTN2_DROMEDmngenetic
18545683
SPIN_DROMEspingenetic
23154413
SGPL_DROMESplygenetic
23154413
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DMDA_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1832; SER-1838 ANDSER-3207, AND MASS SPECTROMETRY.

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