SPIN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPIN_DROME
• UniProt AC: Q9GQQ0
• Protein Name: Protein spinster
• Gene Name: spin
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 605
• Subcellular Localization: Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein .
• Protein Description: Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta-mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage..
• Protein Sequence: MSLKHQKQSYQPLPTAAAMDNPAMIQSSGSSGSSSSEEGGSREDVANLSPLGLPTTYSSQQLMPSDTDSMEEERHRLRPHHHHHHPLGEHHHIPGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKMQPGNENIVQDDVAFNFGVITMLAGLLGVPLGSFLSQYLVKRYPTADPVICAFGLLVSAPLLTGACLLVNSNSVGTYALIFFGQLALNLNWAIVADILLYVVVPTRRSTAEAFQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNATQVIAEATTSLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNATRGLQDATAQQQQRDERGQIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
149	N-linked_Glycosylation	RNDFDIGNDSAGLLQ HHCCCCCCCHHHHHH	40.16	-
252	Phosphorylation	YFAIPVGSGLGYIVG HHHCCCCCCCCHHCC	30.95	19429919
256	Phosphorylation	PVGSGLGYIVGSKTA CCCCCCCHHCCCCCH	9.47	19429919
260	Phosphorylation	GLGYIVGSKTAHLAN CCCHHCCCCCHHHCC	18.88	19429919
298	Phosphorylation	KDPVRGHSEGSHNLE HCCCCCCCCCCCCCC	46.61	22668510
301	Phosphorylation	VRGHSEGSHNLEATT CCCCCCCCCCCCCCC	12.73	22668510
307	Phosphorylation	GSHNLEATTYKQDIK CCCCCCCCCHHHHHH	22.68	22668510
319	N-linked_Glycosylation	DIKALVRNRSFMLST HHHHHHHCCCHHHHC	36.15	-
519	N-linked_Glycosylation	VAGSAISNATQVIAE HHHHHHHHHHHHHHH	40.68	-
583	N-linked_Glycosylation	FIIKDKYNATRGLQD HHHHHHHHCCCCHHH	40.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPIN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPIN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPIN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DECA_DROME	dpp	genetic	21562262
HRS_DROME	Hrs	genetic	21562262
MAD_DROME	Mad	genetic	21562262
WNTG_DROME	wg	genetic	21562262

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.