GCP2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCP2_DROME
• UniProt AC: Q9XYP7
• Protein Name: Gamma-tubulin complex component 2 homolog
• Gene Name: Grip84
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 852
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
• Protein Sequence: MYALLVFVERYSECKPVSESSSSTSLSAMGLPHGNKTSDVNSAAGSVPTTLAIASTSTILTTSQNVSGSTRLSLTQSQDFPTSTPVNCKKATESDTTPVVFVRRGPMDRNRGAGKDERNDLSVIKERVLNAVSDQSLSGYRSVTNKTGNSPKSMPNDLVTLTDVPDEYRTHLLWEYYKVDGDKVPRAEIAAMPLLSQESMLLDELLHCLTGIRESLLVPQKPIISAVGLAKYDTDFDIHTHLDRSLTHQVREILPLASYFMGVQKIIAATDGLGQVMNSLNEALQELTHDFYLIIVQAEQELRHNRLTLQKLLYYLQPTMWVMHEVWSSLVIIQLSDSRDAEVLTYLHERIKRLEGNKDAQQLIIGLVRKAAKPYMRMLQMWIQKGVIVDRHREFLVVDNEVIHRDELPEHYSDDYWERRYTLRDEQIPSFLAKYSDKILRTGKYLNVIRQCGKRVMPTQEMNLEFDPTSERHVSVINDAYYFAARMLLDVLLTENDLMGHLQSVKRYLLLNQGDFTMQFMDACEDELTKNVDHVLPMTLENLLGLTLRISSARNDPYKDDLHCELLPYDLVTQMSKIMKKEENWQAQPRLDLSGLECFAFTYEVKWPCSLVLNHISISKYQMLFRQLFYCKHVERQLCKIWKENSIARQFEPQAASLYRAAFTLRQRMMNAIQNLEYYMMIEIIEPNWHIFIEKMKTVENVDNVLRLHQDFLDSCLKNCMLTESSHLNRSIFKLCKICLKYCEFIQITQRYFQDAELRSMVRDSADSSESEQESLHCPQIETPLDPTDTFSERVRRFDLEFTQLLISFLKQINSMAKKNTADCFMNLVHRINFNAFYTDQMDKMCVEDAIG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	YSECKPVSESSSSTS HCCCCCCCCCCCCCC	40.04	21082442
21	Phosphorylation	CKPVSESSSSTSLSA CCCCCCCCCCCCHHC	25.02	21082442
22	Phosphorylation	KPVSESSSSTSLSAM CCCCCCCCCCCHHCC	47.09	21082442
24	Phosphorylation	VSESSSSTSLSAMGL CCCCCCCCCHHCCCC	35.32	22817900
25	Phosphorylation	SESSSSTSLSAMGLP CCCCCCCCHHCCCCC	23.44	21082442
73	Phosphorylation	VSGSTRLSLTQSQDF CCCCCEEEEEECCCC	26.53	10037793
75	Phosphorylation	GSTRLSLTQSQDFPT CCCEEEEEECCCCCC	23.85	22817900
97	Phosphorylation	KATESDTTPVVFVRR CCCCCCCCCEEEEEC	21.05	28490779
122	Phosphorylation	KDERNDLSVIKERVL CCCCCCHHHHHHHHH	25.35	22817900
136	Phosphorylation	LNAVSDQSLSGYRSV HHHCCCCCCCCCCCC	29.50	21082442
150	Phosphorylation	VTNKTGNSPKSMPND CCCCCCCCCCCCCCC	34.74	30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCP2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCP2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCP2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRP68_DROME	Srp68	physical	14605208
TBG1_DROME	gammaTub23C	physical	11134079
GCP3_DROME	Grip91	physical	11134079
TBG1_DROME	gammaTub23C	physical	22729084
GCP4_DROME	Grip75	physical	10037793
GCP4_DROME	Grip75	physical	22729084
TBG2_DROME	gammaTub37C	physical	22729084
GCP3_DROME	Grip91	physical	10037793
GCP3_DROME	Grip91	physical	22729084

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, AND MASSSPECTROMETRY.
PubMed: 17372656