SRP68_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRP68_DROME
• UniProt AC: Q9VSS2
• Protein Name: Signal recognition particle subunit SRP68
• Gene Name: Srp68
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 604
• Subcellular Localization: Cytoplasm.
• Protein Description: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Srp68 binds the 7S RNA, Srp72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity)..
• Protein Sequence: MVVQEDNPNTGDVQEKTETAPVAEPSKIFTVEILHMIKDAQQQHGLRHGDFQRYRGYCSRRIRRLRKALKYPQGDKRHFKRRDVTIGQLTGKKADERFIHIPLICAERAWAYAMQLKQESNTEPRKRFHLVNKLRRACFYALQLQELCNTEAFDARTKLECEAYVAWMHGTLHFELQLWKTAGEHLKRAQVVYENLGKALPEDEQELYRAKVNEFTPNLRYCAYNISGGASGGKIDEILELRAQGVLENLDVLVSQTKTESSEGLQTIDWRGRKVTVRPEKVRLFLLSAQELDKSLAKTTKQDAKIELIERILMDCKDAIQAVRDEIKQDPKLRSLTTGQTVSGVQYLLAYLSYIRHSRTLQRNLCLVEQAKLNFYDPNLQSQQNVGDGKRVRPQDLARLYEIILQNVTEMQQINGLEDDATYQSEVENLAITFKAFRCYYIALTLIDIKKWKEAVALYERASNYATEALKGKSSPEFQLQEELKKVVSAIDGCKFSAHAYSVLEDDNSEESGTTTKSQKTTKPLYERLSLYKEDQSLHTKAPNVFKLTPDMEPIPCKPIFFDLAMTYVELPSLEGKLESPGKKGASITGFVKGFLGWGGGGNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	Ubiquitination	TIGQLTGKKADERFI CHHHHCCCCCCHHEE	39.28	31113955
530	Phosphorylation	KPLYERLSLYKEDQS CCHHHHHHHHHHCCC	35.55	22817900
580	Phosphorylation	SLEGKLESPGKKGAS CCCCCCCCCCCCCCC	49.76	19429919
587	Phosphorylation	SPGKKGASITGFVKG CCCCCCCCCHHHCCC	29.38	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRP68_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRP68_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRP68_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED19_DROME	MED19	physical	14605208
ANX11_DROME	AnxB11	physical	14605208
TIP60_DROME	Tip60	physical	14605208
DTBP1_DROME	Dysb	physical	14605208
EF1A1_DROME	Ef1alpha48D	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.