GCP4_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCP4_DROME
• UniProt AC: Q9VKU7
• Protein Name: Gamma-tubulin complex component 4 homolog
• Gene Name: Grip75
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 650
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
• Protein Description: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome..
• Protein Sequence: MIHDLLLACRSHNPEQLGIKAFNETTVIDQFIHPCEREIFMDIIKIIKVYQEVEQFTHSSGRKSDTHGELPDSLHGYYLLNLAKGIEMALEEYYAEIGRLEKYCLGNERNSLSYVYNALYAKFPLLVFMRNLITEIHVLNLRGCVLLHNLHQQCEHGDIQLEKAIKIIMKPVKNAFFSSLAHWLLFGVIDDVHSEFFIKFTPTDAVDGSSFSKSATCSLLSAEKNPEDYIWQYEVNMSQLPGFFSIVLAEKVLFVGQTVLVFKMGRNVKVKNKTDPLAAKLAELDSDDIYQLWSGRESEFFKMVVDLSNEDTINVFRLEKVIIDIKNYVSARLSEIAVNEVDLERQMGLIKDFFLLGRGEFYLEFCSQMVGTMETYREERFKNVTRSFELAATVTGITDDLDKFSLICQRSTSEPDDTSDFNFLQGLSLKYEYEWPLNLLFSPTTIERYNNIFRFLLIIRTYQYEIQRVWAKQTWRAKSAKDVPPNNKIITLRNYLMFFLNNMQYYIQVDVLESQFGILMNVIKSRSDFEVIQRAHTVFLANVLSHCFLLNESETQLNVTGSQNRNPIYGTLLKLFGICEKFAHMTQTKDPSDDLEDEVDQLNESFGVQIASLIQLLVDVKSASCLGPLSQLLLRLDFNCWFSASHNTSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Phosphorylation	THSSGRKSDTHGELP HCCCCCCCCCCCCCC	46.51	21082442
209	Phosphorylation	PTDAVDGSSFSKSAT CCCCCCCCCCCCCCC	24.60	27626673
210	Phosphorylation	TDAVDGSSFSKSATC CCCCCCCCCCCCCCH	38.78	27626673
214	Phosphorylation	DGSSFSKSATCSLLS CCCCCCCCCCHHHHC	27.84	22817900
216	Phosphorylation	SSFSKSATCSLLSAE CCCCCCCCHHHHCCC	15.09	22817900
218	Phosphorylation	FSKSATCSLLSAEKN CCCCCCHHHHCCCCC	28.17	22817900
537	Phosphorylation	EVIQRAHTVFLANVL HHHHHHHHHHHHHHH	16.39	22817900
560	Phosphorylation	SETQLNVTGSQNRNP CCCCEECCCCCCCCC	30.00	22817900
562	Phosphorylation	TQLNVTGSQNRNPIY CCEECCCCCCCCCHH	18.21	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCP4_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCP4_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCP4_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBG2_DROME	gammaTub37C	physical	12431375

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214; THR-216 ANDSER-218, AND MASS SPECTROMETRY.
PubMed: 18327897