dbPTM

GCM_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GCM_DROME
UniProt AC	Q27403
Protein Name	Transcription factor glial cells missing
Gene Name	gcm
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	504
Subcellular Localization	Nucleus .
Protein Description	Transcription factor that induces gliogenesis. It determines the choice between glial and neuronal fates. Also has a role in the differentiation of the plasmatocyte/macrophage lineage of hemocytes..
Protein Sequence	MVLNGMPITMPVPMPVPMPVPSPPATKSRVAIDWDINDSKMPSVGEFDDFNDWSNGHCRLIYSVQSDEARKHASGWAMRNTNNHNVNILKKSCLGVLLCSAKCKLPNGASVHLRPAICDKARRKQQGKQCPNRNCNGRLEIQACRGHCGYPVTHFWRRDGNGIYFQAKGTHDHPRPEAKGSTEARRLLAGGRRVRSLAVMLARESALSDKLSSLRPTKRQAKTQSIQESKRRRMGASDVLETKQELVVPPTTYLPTSTPTHSTNFNQSQGSYVPAGQGSVISQWNREIHYETEDPCYANGMYSYDMLHSPLSAHSSTGSYYQENKPQQLQHSQYQQQLSPQQHVPVSYDPSQPISSSLQCGMPSYEICDDTSSLTSSSGYCSEDYGYYNGYLPNSLDVSNGSQSQNLSQDASFYTTSSEIFSVFESTLNGGGTSGVDLIYDEATAYQQHQQQGTFPHLTNYQQEPQDQMQSADYYYSNTGVDNSWNIQMDATYHPVNSTDPIYC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
237	Phosphorylation	KRRRMGASDVLETKQ HHHHCCHHHHHHHCH	23.63	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GCM_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GCM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GCM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP2A_DROME	mts	physical	14605208
JAK_DROME	hop	genetic	19598118
DOME_DROME	dome	genetic	19598118
AFF4_DROME	lilli	genetic	23300465
GCM2_DROME	gcm2	genetic	11532931
C2D1_DROME	l(2)gd1	genetic	23300465
ESC_DROME	esc	genetic	23300465
SUH_DROME	Su(H)	genetic	23300465
ESCA_DROME	esg	genetic	23300465
SNAI_DROME	sna	genetic	23300465
BRAT_DROME	brat	genetic	23300465
E2F2_DROME	E2f2	genetic	23300465
EZ_DROME	E(z)	genetic	23300465
FGFR2_DROME	btl	genetic	12781136
BRM_DROME	brm	genetic	23300465
ASH1_DROME	ash1	genetic	23300465
PC_DROME	Pc	genetic	23300465
DFD_DROME	Dfd	genetic	19282966
TRX_DROME	trx	genetic	23300465
OSA_DROME	osa	genetic	23300465
FRU_DROME	fru	genetic	23300465
STAT_DROME	Stat92E	genetic	19598118
LOLA1_DROME	lola	genetic	23300465
LOLA2_DROME	lola	genetic	23300465
LOLA3_DROME	lola	genetic	23300465
LOLA4_DROME	lola	genetic	23300465
LOLA6_DROME	lola	genetic	23300465
LOLA5_DROME	lola	genetic	23300465
NU301_DROME	E(bx)	genetic	23300465
TTKB_DROME	ttk	genetic	23300465
TTKA_DROME	ttk	genetic	23300465
IMA_DROME	Pen	physical	19598118
CHN_DROME	chn	physical	19598118
Y2199_DROME	CG2199	physical	19598118
MICAL_DROME	Mical	physical	19598118
KPC1_DROME	Pkc53E	physical	28051179

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GCM_DROME

Related Literatures of Post-Translational Modification