| UniProt ID | BRAT_DROME | |
|---|---|---|
| UniProt AC | Q8MQJ9 | |
| Protein Name | Brain tumor protein | |
| Gene Name | brat | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1037 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cell cortex . In embryonic and larval neuroblasts, colocalizes with mira throughout mitosis using it as an adapter to segregate into one of the two daughter cells during asymmetric cell division. Accumulates at the apical cell | |
| Protein Description | A NHL-domain family protein that functions a translational repressor to inhibit cell proliferation. [PubMed: 11274060 Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR] | |
| Protein Sequence | MASSPTPSLDSMRGGANSIESYEHAGYLSDSPLTLSGSSPPASDSAICSDEYTGGSSVKSRSEVTVINGHHPISASVSSSSSASSSSCSSSSSSSSSSSSSSSSTSGLSGCGSTSSSVISANNVASSNGPGVIGSNLQSSNNGGNSGISSLVVGAGKGSNSSSNSSSSNTSANGSPPRCTACKSKCSDAVAKCFECQSYLCANCVTAHEFMHCFNGHNVCLIKGFEASTTGTPLSVGSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAAQANSQEQQREDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQFFASMLDERKTELLKELETLYTAKVNSNNSWQQRSRDLIDKGLATCEAVERSPAPPSSLLTEALLLRKSLEQQLQTGIQEMQLPFEIEFMSNYQSIQAGVRNTFGYIRANSSDGGPTGMSLTSNGHGKQPPIARPTQSASNSSASSAGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLDSSSSAGGAVGAFSNGGLLLGGRDRNALAVEQHFGELMPKRGGGGYTGSNGSATSAVAHYNPYEKWSNGGSDNLFSSVTSGVSGSSAVADAFASLSAVGGSVVSGAGAGGSTVSSESLLDLTNKLLSATIYPPKSQIKRQKMIYHCKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRFKFQFGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFGATILQHPRGVTVDNKGRIIVVECKVMRVIIFDQNGNVLHKFGCSKHLEFPNGVVVNDKQEIFISDNRAHCVKVFNYEGQYLRQIGGEGITNYPIGVGINSNGEILIADNHNNFNLTIFTQDGQLISALESKVKHAQCFDVALMDDGSVVLASKDYRLYIYRYVQLAPVGM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASSPTPSLD -----CCCCCCCCHH | 49.02 | 19429919 | |
| 4 | Phosphorylation | ----MASSPTPSLDS ----CCCCCCCCHHH | 39.59 | 19429919 | |
| 6 | Phosphorylation | --MASSPTPSLDSMR --CCCCCCCCHHHCC | 27.70 | 19429919 | |
| 8 | Phosphorylation | MASSPTPSLDSMRGG CCCCCCCCHHHCCCC | 47.49 | 19429919 | |
| 11 | Phosphorylation | SPTPSLDSMRGGANS CCCCCHHHCCCCCCC | 18.70 | 27626673 | |
| 410 | Phosphorylation | GNSDQNLTKVKLQYQ CCCCCCCHHHHHHHH | 41.14 | 28490779 | |
| 486 | Phosphorylation | RSPAPPSSLLTEALL CCCCCCHHHHHHHHH | 32.92 | 21082442 | |
| 685 | Phosphorylation | AVAHYNPYEKWSNGG CEEECCCCCCCCCCC | 26.88 | 18281928 | |
| 718 | Phosphorylation | ADAFASLSAVGGSVV HHHHHHHHCCCCEEC | 20.57 | 22668510 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BRAT_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BRAT_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BRAT_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| Y1505_DROME | CG11505 | physical | 14605208 | |
| ARM_DROME | arm | genetic | 24257623 | |
| SGG_DROME | sgg | genetic | 24257623 | |
| BTD_DROME | btd | genetic | 25285447 | |
| KC1A_DROME | CkIalpha | genetic | 24257623 | |
| MAD_DROME | Mad | genetic | 23884941 | |
| DPN_DROME | dpn | genetic | 24550111 | |
| BRM_DROME | brm | genetic | 24550111 | |
| PROS_DROME | pros | genetic | 16564014 | |
| PROS_DROME | pros | genetic | 16774999 | |
| TRX_DROME | trx | genetic | 25285447 | |
| OSA_DROME | osa | genetic | 24550111 | |
| ESMC_DROME | E(spl)mgamma-HLH | genetic | 24550111 | |
| AXN_DROME | Axn | genetic | 24257623 | |
| WHITE_DROME | w | physical | 26527002 | |
| MYC_DROME | dm | physical | 26527002 | |
| SIR2_DROME | Sir2 | physical | 26527002 | |
| DPN_DROME | dpn | physical | 26527002 | |
| STAU_DROME | stau | physical | 26527002 | |
| STAU_DROME | stau | physical | 26423004 | |
| KNIR_DROME | kni | physical | 26527002 | |
| PC_DROME | Pc | physical | 26527002 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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