DPN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPN_DROME
• UniProt AC: Q26263
• Protein Name: Protein deadpan
• Gene Name: dpn
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 435
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor of genes that require a bHLH protein for their transcription. [PubMed: 1427077]
• Protein Sequence: MDYKNDINSDDDFDCSNGYSDSYGSNGRMSNPNGLSKAELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSNGYRGGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAPAIQMGGLQLIPSRLPSGEFALIMPNTGSAAPPPGPFAWPGSAAGVAAGTASAALASIANPTHLNDYTQSFRMSAFSKPVNTSVPANLPENLIHTLPGQTQLPVKNSTSPPLSPISSISSHCEESRAASPTVDVMSKHSFAGVFSTPPPTSAETSFNTSGSLNLSAGSHDSSGCSRPLAHLQQQQVSSTSGIAKRDREAEAESSDCSLDEPSSKKFLAGAIEKSSSAWRPW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
407	Phosphorylation	DREAEAESSDCSLDE HHHHHHHHCCCCCCC	38.23	22817900
408	Phosphorylation	REAEAESSDCSLDEP HHHHHHHCCCCCCCC	33.86	22817900
411	Phosphorylation	EAESSDCSLDEPSSK HHHHCCCCCCCCCHH	43.79	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNAE_DROME	eag	genetic	26258683
PROS_DROME	pros	genetic	23056424
SISA_DROME	sisA	physical	7651341
DA_DROME	da	physical	7651341
SIR2_DROME	Sir2	physical	12086602
DPN_DROME	dpn	physical	7651341
HAIR_DROME	h	physical	14871887
ESMC_DROME	E(spl)mgamma-HLH	physical	22357926
GROU_DROME	gro	physical	16762837
GROU_DROME	gro	physical	8001118
GROU_DROME	gro	physical	9524128

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407; SER-408 ANDSER-411, AND MASS SPECTROMETRY.
PubMed: 18327897