PROS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PROS_DROME
• UniProt AC: P29617
• Protein Name: Homeobox protein prospero
• Gene Name: pros
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1703
• Subcellular Localization: Nucleus . Cytoplasm, cell cortex . Cytoplasm . Dispersed in the cytoplasm of mitotic ganglion mother cells (GMCs) and neuroblast-like cell type.
• Protein Description: Homeodomain protein that controls neuronal identity. [PubMed: 1842358 As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd]
• Protein Sequence: MMSSEEYEADCFGLYSDENNVLLKANEPETTAATKQQHQPQFQQQQQQQQQQQQHHHQHQQPPPSSNGHTSPIPSQVNGDGSAANCGESGKTNTNTGSHSHSNSGNTNTDADKEQEREKAKEKANEEESEDSDDDVVVVLEGCEGNASSSSSSSNSNSNASSNNHKAAATTTTTATTANHCNRSGGSSRSHRSARSSRQISQSTAVGKTTTCAAKKPTAAQATTTTAKNSNSNSNVNVNVNVNSNGSGNGNANSKVNRRSRQRSLSKDINNQPASSNSNSNSSNNSSNSNGGATATAAGFMSSAAAAAAGAAGGGALFQPQSVSTANSSSSNNNNSSTPAALATHSPTSNSPVSGASSASSLLTAAFGNLFGGSSAKMLNELFGRQMKQAQDATSGLPQSLDNAMLAAAMETATSAELLIGSLNSTSKLLQQQHNNNSIAPANSTPMSNGTNASISPGSAHSSSHSHQGVSPKGSRRVSACSDRSLEAAAADVAGGSPPRAASVSSLNGGASSGEQHQSQLQHDLVAHHMLRNILQGKKELMQLDQELRTAMQQQQQQLQEKEQLHSKLNNNNNNNIAATANNNNNTTMESINLIDDSEMADIKIKSEPQTAPQPQQSPHGSSHSSRSGSGSGSHSSMASDGSLRRKSSDSLDSHGAQDDAQDEEDAAPTGQRSESRAPEEPQLPTKKESVDDMLDEVELLGLHSRGSDMDSLASPSHSDMMLLDKDDVLDEDDDDDCVEQKTSGSGCLKKPGMDLKRARVENIVSGMRCSPSSGLAQAGQLQVNGCKKRKLYQPQQHAMERYVAAAAGLNFGLNLQSMMLDQEDSESNELESPQIQQKRVEKNALKSQLRSMQEQLAEMQQKYVQLCSRMEQESECQELDQDQDVEQEQEPDNGSSDHIELSPSPTLTGDGDVSPNHKEETGQERPGSSSPSPSPLKPKTSLGESSDSGANMLSQMMSKMMSGKLHNPLVGVGHPALPQGFPPLLQHMGDMSHAAAMYQQFFFEQEARMAKEAAEQQQQQQQQQQQQQQQQQQEQQRRFEQEQQEQQRRKEEQQQQIQRQQQHLQQLQQQQMEQQHVATAAPRPQMHHPAPARLPTRMGGAAGHTALKSELSEKFQMLRANNNSSMMRMSGTDLEGLADVLKSEITTSLSALVDTIVTRFVHQRRLFSKQADSVTAAAEQLNKDLLLASQILDRKSPRTKVADRPQNGPTPATQSAAAMFQAPKTPQGMNPVAAAALYNSMTGPFCLPPDQQQQQQTAQQQQSAQQQQQSSQQTQQQLEQNEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDGVVPPTGGPPSTPQQQQQQQQQQQQQQQQQQQQASNGGNSNATPAQSPTRSSGGAAYHPQPPPPPPPMMPVSLPTSVAIPNPSLHESKVFSPYSPFFNPHAAAGQATAAQLHQHHQQHHPHHQSMQLSSSPPGSLGALMDSRDSPPLPHPPSMLHPALLAAAHHGGSPDYKTCLRAVMDAQDRQSECNSADMQFDGMAPTISFYKQMQLKTEHQESLMAKHCESLTPLHSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
179	Phosphorylation	TTTATTANHCNRSGG CCCHHHCCCCCCCCC	37.85	18327897
182	Phosphorylation	ATTANHCNRSGGSSR HHHCCCCCCCCCCCC	33.33	18327897
185	Phosphorylation	ANHCNRSGGSSRSHR CCCCCCCCCCCCCCC	36.44	18327897
197	Phosphorylation	SHRSARSSRQISQST CCCCHHHCCCCCHHC	23.74	18327897
351	Phosphorylation	THSPTSNSPVSGASS CCCCCCCCCCCCCHH	26.84	18327897
354	Phosphorylation	PTSNSPVSGASSASS CCCCCCCCCCHHHHH	31.84	18327897
479	Phosphorylation	PKGSRRVSACSDRSL CCCCCCCCCCCCCHH	23.03	22817900
482	Phosphorylation	SRRVSACSDRSLEAA CCCCCCCCCCHHHHH	35.46	22817900
485	Phosphorylation	VSACSDRSLEAAAAD CCCCCCCHHHHHHHH	35.24	22817900
497	Phosphorylation	AADVAGGSPPRAASV HHHHHCCCCCCCCCC	30.71	22817900
503	Phosphorylation	GSPPRAASVSSLNGG CCCCCCCCCHHCCCC	22.88	22817900
651	Phosphorylation	LRRKSSDSLDSHGAQ CCCCCCCCCCCCCCC	35.70	22817900
654	Phosphorylation	KSSDSLDSHGAQDDA CCCCCCCCCCCCCCC	29.16	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PROS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PROS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PROS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESCA_DROME	esg	genetic	22049409
CCNE_DROME	CycE	physical	19914234

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479; SER-482; SER-485;SER-497; SER-651 AND SER-654, AND MASS SPECTROMETRY.
PubMed: 18327897