UniProt ID | PROS_DROME | |
---|---|---|
UniProt AC | P29617 | |
Protein Name | Homeobox protein prospero | |
Gene Name | pros | |
Organism | Drosophila melanogaster (Fruit fly). | |
Sequence Length | 1703 | |
Subcellular Localization | Nucleus . Cytoplasm, cell cortex . Cytoplasm . Dispersed in the cytoplasm of mitotic ganglion mother cells (GMCs) and neuroblast-like cell type. | |
Protein Description | Homeodomain protein that controls neuronal identity. [PubMed: 1842358 As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd] | |
Protein Sequence | MMSSEEYEADCFGLYSDENNVLLKANEPETTAATKQQHQPQFQQQQQQQQQQQQHHHQHQQPPPSSNGHTSPIPSQVNGDGSAANCGESGKTNTNTGSHSHSNSGNTNTDADKEQEREKAKEKANEEESEDSDDDVVVVLEGCEGNASSSSSSSNSNSNASSNNHKAAATTTTTATTANHCNRSGGSSRSHRSARSSRQISQSTAVGKTTTCAAKKPTAAQATTTTAKNSNSNSNVNVNVNVNSNGSGNGNANSKVNRRSRQRSLSKDINNQPASSNSNSNSSNNSSNSNGGATATAAGFMSSAAAAAAGAAGGGALFQPQSVSTANSSSSNNNNSSTPAALATHSPTSNSPVSGASSASSLLTAAFGNLFGGSSAKMLNELFGRQMKQAQDATSGLPQSLDNAMLAAAMETATSAELLIGSLNSTSKLLQQQHNNNSIAPANSTPMSNGTNASISPGSAHSSSHSHQGVSPKGSRRVSACSDRSLEAAAADVAGGSPPRAASVSSLNGGASSGEQHQSQLQHDLVAHHMLRNILQGKKELMQLDQELRTAMQQQQQQLQEKEQLHSKLNNNNNNNIAATANNNNNTTMESINLIDDSEMADIKIKSEPQTAPQPQQSPHGSSHSSRSGSGSGSHSSMASDGSLRRKSSDSLDSHGAQDDAQDEEDAAPTGQRSESRAPEEPQLPTKKESVDDMLDEVELLGLHSRGSDMDSLASPSHSDMMLLDKDDVLDEDDDDDCVEQKTSGSGCLKKPGMDLKRARVENIVSGMRCSPSSGLAQAGQLQVNGCKKRKLYQPQQHAMERYVAAAAGLNFGLNLQSMMLDQEDSESNELESPQIQQKRVEKNALKSQLRSMQEQLAEMQQKYVQLCSRMEQESECQELDQDQDVEQEQEPDNGSSDHIELSPSPTLTGDGDVSPNHKEETGQERPGSSSPSPSPLKPKTSLGESSDSGANMLSQMMSKMMSGKLHNPLVGVGHPALPQGFPPLLQHMGDMSHAAAMYQQFFFEQEARMAKEAAEQQQQQQQQQQQQQQQQQQEQQRRFEQEQQEQQRRKEEQQQQIQRQQQHLQQLQQQQMEQQHVATAAPRPQMHHPAPARLPTRMGGAAGHTALKSELSEKFQMLRANNNSSMMRMSGTDLEGLADVLKSEITTSLSALVDTIVTRFVHQRRLFSKQADSVTAAAEQLNKDLLLASQILDRKSPRTKVADRPQNGPTPATQSAAAMFQAPKTPQGMNPVAAAALYNSMTGPFCLPPDQQQQQQTAQQQQSAQQQQQSSQQTQQQLEQNEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDGVVPPTGGPPSTPQQQQQQQQQQQQQQQQQQQQASNGGNSNATPAQSPTRSSGGAAYHPQPPPPPPPMMPVSLPTSVAIPNPSLHESKVFSPYSPFFNPHAAAGQATAAQLHQHHQQHHPHHQSMQLSSSPPGSLGALMDSRDSPPLPHPPSMLHPALLAAAHHGGSPDYKTCLRAVMDAQDRQSECNSADMQFDGMAPTISFYKQMQLKTEHQESLMAKHCESLTPLHSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQLE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
179 | Phosphorylation | TTTATTANHCNRSGG CCCHHHCCCCCCCCC | 37.85 | 18327897 | |
182 | Phosphorylation | ATTANHCNRSGGSSR HHHCCCCCCCCCCCC | 33.33 | 18327897 | |
185 | Phosphorylation | ANHCNRSGGSSRSHR CCCCCCCCCCCCCCC | 36.44 | 18327897 | |
197 | Phosphorylation | SHRSARSSRQISQST CCCCHHHCCCCCHHC | 23.74 | 18327897 | |
351 | Phosphorylation | THSPTSNSPVSGASS CCCCCCCCCCCCCHH | 26.84 | 18327897 | |
354 | Phosphorylation | PTSNSPVSGASSASS CCCCCCCCCCHHHHH | 31.84 | 18327897 | |
479 | Phosphorylation | PKGSRRVSACSDRSL CCCCCCCCCCCCCHH | 23.03 | 22817900 | |
482 | Phosphorylation | SRRVSACSDRSLEAA CCCCCCCCCCHHHHH | 35.46 | 22817900 | |
485 | Phosphorylation | VSACSDRSLEAAAAD CCCCCCCHHHHHHHH | 35.24 | 22817900 | |
497 | Phosphorylation | AADVAGGSPPRAASV HHHHHCCCCCCCCCC | 30.71 | 22817900 | |
503 | Phosphorylation | GSPPRAASVSSLNGG CCCCCCCCCHHCCCC | 22.88 | 22817900 | |
651 | Phosphorylation | LRRKSSDSLDSHGAQ CCCCCCCCCCCCCCC | 35.70 | 22817900 | |
654 | Phosphorylation | KSSDSLDSHGAQDDA CCCCCCCCCCCCCCC | 29.16 | 22817900 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PROS_DROME !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PROS_DROME !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PROS_DROME !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ESCA_DROME | esg | genetic | 22049409 | |
CCNE_DROME | CycE | physical | 19914234 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479; SER-482; SER-485;SER-497; SER-651 AND SER-654, AND MASS SPECTROMETRY. |