DA_DROME - dbPTM
DA_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DA_DROME
UniProt AC P11420
Protein Name Protein daughterless
Gene Name da
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 710
Subcellular Localization Nucleus.
Protein Description Daughterless/Achaete-scute complex heterodimers act as transcriptional activators of neural cell fates and are involved in sex determination..
Protein Sequence MATSDDEPMHLYEVFQNCFNKIANKQPTGTVGADRGGGGGYHSPYGSLGVENGMYPSDFNSMHDTVNGGNNRYANASTVDQYFDSAAAGSGGAWCQPQMSSANSYMGQSAYQNSGPLSGHSIDQQQQQVHQADGLGMGGGGGGGVGADGMHCPVTTGLPPISSFRPTSGGIGGPGAGQQAPVNVNVNPPAVFNSPQAHNHNHTVQAQHSALSTAGPLGHHSLNHTPHAHSHTLPLPHALPHGHTLPHPHHSQQNSPAVQSSDAFSGAGASVKVAGAGNSSAAALRQQMYMPADQSISSFGSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGGPSSSYASEMVPVSSLHTMASVFQGVRMEERLDDALNVLRNHCEPEMLAGVNQSLASIDNIDALTSFVPNSPSHLGSGGNSGSVSNTSNAALVHEVLALGAAAAAGTSGQSVGGAGSLASLKLDRSASTSLPKQTKKRKEHTAISNSVPAGVSTTSSLTSLDISDTKPTSSIESSNSGLQQHSQGKGTKRPRRYCSSADEDDDAEPAVKAIREKERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEKAEDGPKLSAQHHMIPQPQQVGGTPGSSYHSQPAQLVPPSSQTISTMTISLPVNQANNGLPPHLQQQQQQQSQLGHAQLPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43PhosphorylationGGGGGYHSPYGSLGV
CCCCCCCCCCCCCCC		16.0122817900
467PhosphorylationLKLDRSASTSLPKQT
HCCCCCCCCCCCCCC		21.5622817900
533PhosphorylationGTKRPRRYCSSADED
CCCCCCCCCCCCCCC		9.6522817900
535PhosphorylationKRPRRYCSSADEDDD
CCCCCCCCCCCCCCC		21.4519429919
536PhosphorylationRPRRYCSSADEDDDA
CCCCCCCCCCCCCCC		35.8619429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DA_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DA_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DA_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FER3_DROMEFer3physical
14605208
AST4_DROMEscgenetic
24190881
DPN_DROMEdpngenetic
8601486
MEF2_DROMEMef2genetic
11112327
ATO_DROMEatogenetic
22078884
MYOD_DROMEnaugenetic
11112327
GFI1_DROMEsensgenetic
16554363
AST4_DROMEscphysical
7623836
AST4_DROMEscphysical
10903170
AST4_DROMEscphysical
8324823
AST4_DROMEscphysical
8565819
AST4_DROMEscphysical
7651341
AST4_DROMEscphysical
7821225
AST4_DROMEscphysical
9486535
AST3_DROMEl(1)scphysical
1915272
AST3_DROMEl(1)scphysical
7821225
AST3_DROMEl(1)scphysical
9486535
ACT1_DROMEAct5Cphysical
24190881
DA_DROMEdaphysical
7651341
ACT2_DROMEAct42Aphysical
24190881
DEI_DROMEtxphysical
9486535
PAX6_DROMEeyphysical
24886829
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DA_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-535 AND SER-536,AND MASS SPECTROMETRY.

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