ACT2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACT2_DROME
• UniProt AC: P02572
• Protein Name: Actin-42A
• Gene Name: Act42A
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.; Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction..
• Protein Sequence: MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MCDEEVAALV -----CCHHHCEEEE	54.51	-
34	Phosphorylation	APRAVFPSIVGRPRH CCCCCCHHHCCCCCC	20.59	22817900
45	Methionine sulfoxide	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	-
45	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	22116028
48	Methionine sulfoxide	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	-
48	Oxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	22116028
51	Acetylation	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	21791702
53	Phosphorylation	VGMGQKDSYVGDEAQ EECCCCCCCCCCHHH	28.84	21082442
61	Phosphorylation	YVGDEAQSKRGILTL CCCCHHHCCCCEEEE	31.22	27794539
67	Phosphorylation	QSKRGILTLKYPIEH HCCCCEEEEECEECC	21.20	22668510
69	Acetylation	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	21791702
74	Methylation	TLKYPIEHGIVTNWD EEECEECCCCCCCHH	31.81	30526847
107	Phosphorylation	EEHPVLLTEAPLNPK CCCCEEEEECCCCCC	26.41	22817900
192	Acetylation	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	21791702
234	Phosphorylation	EMATAASSSSLEKSY HHHHHHCCCCCCCCE	21.15	21082442
235	Phosphorylation	MATAASSSSLEKSYE HHHHHCCCCCCCCEE	36.13	21082442
236	Phosphorylation	ATAASSSSLEKSYEL HHHHCCCCCCCCEEC	42.36	21082442
241	Phosphorylation	SSSLEKSYELPDGQV CCCCCCCEECCCCCE	32.33	29892262
292	Ubiquitination	KCDVDIRKDLYANTV CCCCEECCHHHCCCE	53.04	31113955
316	Ubiquitination	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	31113955
324	Phosphorylation	EITALAPSTMKIKIV HHHHHCCCCEEEEEE	35.21	27794539
327	Acetylation	ALAPSTMKIKIVAPP HHCCCCEEEEEECCC	40.72	21791702
366	Phosphorylation	SKQEYDESGPSIVHR HCCCCCCCCCCCCCC	53.78	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACT2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACT2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACT2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AST5_DROME	ac	physical	24190881
AST4_DROME	sc	physical	24190881

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.