ACT1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACT1_DROME
• UniProt AC: P10987
• Protein Name: Actin-5C
• Gene Name: Act5C
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.; Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction..
• Protein Sequence: MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MCDEEVAALV -----CCHHHCEEEE	54.51	-
34	Phosphorylation	APRAVFPSIVGRPRH CCCCCCHHHCCCCCC	20.59	22817900
44	Sulfoxidation	GRPRHQGVMVGMGQK CCCCCCCEEEECCCC	1.95	24212093
45	Methionine sulfoxide	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	-
45	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	22116028
47	Sulfoxidation	RHQGVMVGMGQKDSY CCCCEEEECCCCCCC	9.08	24212093
48	Methionine sulfoxide	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	-
48	Oxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	22116028
53	Phosphorylation	VGMGQKDSYVGDEAQ EECCCCCCCCCCHHH	28.84	21082442
61	Phosphorylation	YVGDEAQSKRGILTL CCCCHHHCCCCEEEE	31.22	27794539
67	Phosphorylation	QSKRGILTLKYPIEH HCCCCEEEEECEECC	21.20	22668510
74	Methylation	TLKYPIEHGIVTNWD EEECEECCCCCCCHH	31.81	-
107	Phosphorylation	EEHPVLLTEAPLNPK CCCCEEEEECCCCCC	26.41	22817900
234	Phosphorylation	EMATAASSSSLEKSY HHHHHHCCCCCCCCE	21.15	21082442
235	Phosphorylation	MATAASSSSLEKSYE HHHHHCCCCCCCCEE	36.13	21082442
236	Phosphorylation	ATAASSSSLEKSYEL HHHHCCCCCCCCEEC	42.36	21082442
241	Phosphorylation	SSSLEKSYELPDGQV CCCCCCCEECCCCCE	32.33	29892262
324	Phosphorylation	EITALAPSTMKIKII HHHHHCCCCEEEEEE	35.21	27794539
366	Phosphorylation	SKQEYDESGPSIVHR HCCCCCCCCCCCCCC	53.78	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACT1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACT1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACT1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAMO_DROME	tamo	physical	14605208
NOC_DROME	noc	physical	14605208
ATG5_DROME	Atg5	physical	22036573
CDKAL_DROME	CG6550	physical	22036573
UFL1_DROME	CG1104	physical	22036573
DNAT_DROME	Dat	physical	22036573
OSGEP_DROME	CG4933	physical	22036573
SRF_DROME	bs	physical	22036573
CP2B_DROME	Capa	physical	22036573
ACT2_DROME	Act42A	genetic	12034866

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.