dbPTM

OSGEP_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OSGEP_DROME
UniProt AC	Q9VV41
Protein Name	Probable tRNA N6-adenosine threonylcarbamoyltransferase {ECO:0000255\|HAMAP-Rule:MF_03180}
Gene Name	Tcs3 {ECO:0000312\|FlyBase:FBgn0283681}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	347
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity..
Protein Sequence	MVCALGIEGSANKIGIGIIRDGKVLANVRRTYITPPGEGFLPKETAKHHREAILGLVESSLKEAQLKSSDLDVICYTKGPGMAPPLLVGAIVARTLSLLWNIPLLGVNHCIGHIEMGRLITGAQNPTVLYVSGGNTQVIAYSNKRYRIFGETIDIAVGNCLDRFARIIKLSNDPSPGYNIEQLAKSSNRYIKLPYVVKGMDVSFSGILSYIEDLAEPGKRQNKRKKPQEEEVNNYSQADLCYSLQETIFAMLVEITERAMAHCGSNEVLIVGGVGCNERLQEMMRIMCEERGGKLFATDERYCIDNGLMIAHAGAEMFRSGTRMPFEESYVTQRFRTDEVLVSWRDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
203	Phosphorylation	VVKGMDVSFSGILSY EECCCCEEHHHHHHH	14.94	22817900
298	Phosphorylation	RGGKLFATDERYCID HCCEEEECCCCEEEC	30.93	22817900
302	Phosphorylation	LFATDERYCIDNGLM EEECCCCEEECCCCE	7.54	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OSGEP_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OSGEP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OSGEP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OSGEP_DROME

Related Literatures of Post-Translational Modification