NOC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOC_DROME
• UniProt AC: Q24423
• Protein Name: Zinc finger protein Noc
• Gene Name: noc
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 537
• Protein Description: May negatively regulate Notch-induced cell proliferation in the eye-head primordium. Required for development of the supraesophageal ganglion and ocelli. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Plays a role in tracheal development..
• Protein Sequence: MVVLEGGGGVVTIGNNQYLQPDYLAPLPTTMDAKKSPLALLAQTCSQIGADSSAVKPLLAMDKNKTKPGACSSSSNSSSSSGSAEISAAKSPSGQAKSPKSSTPISSTATSASLSNTSTGEIKLAFKPYETNVLSHQNQNSFKSSSSLDAEPTRPSSKNSSSAQERVPSRSKSNATPTDGGKAEISAHDSSSSRKTVSPSGSSQRGASPIVRSGMEVLNNANGTAQHPKEMSSMAAAAAAAAAAYKAAGPYGLNPLSALCCPPGMEQHANPAFRPPFAGGFSHHHAAMLAVAANGGYPGGAPGGGPAGQPNPYISYQRIKTPAGGEAIVPVCKDPYCQGCPYSAHTQQMLMGAPCPAGCTQCEHQKYGLAMASAAGLPPAHPYSQAAAAAAANAAAARSAPYVCSWVVGDAYCGKRFQTSDELFSHLRTHTGNLSDPAAAAAALAQSQAQSLLGTLFPPSALRAGYPTPPLSPMSAAAAAARYHPYAKPPPGALAGGPSPFGAAGAFNPAAAAAAAALGPYYSPYAMYGQRMGAAHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	ISAAKSPSGQAKSPK EEEECCCCCCCCCCC	51.10	22817900
98	Phosphorylation	SPSGQAKSPKSSTPI CCCCCCCCCCCCCCC	40.34	22817900
156	Phosphorylation	DAEPTRPSSKNSSSA CCCCCCCCCCCCCCH	51.13	27794539
157	Phosphorylation	AEPTRPSSKNSSSAQ CCCCCCCCCCCCCHH	38.24	22817900
208	Phosphorylation	GSSQRGASPIVRSGM CCCCCCCCCCHHHHH	20.27	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOC_DROME	noc	physical	14605208
ELBOW_DROME	elB	physical	12117809

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-157 AND SER-208,AND MASS SPECTROMETRY.
PubMed: 18327897