UFL1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UFL1_DROME
• UniProt AC: Q9VI55
• Protein Name: E3 UFM1-protein ligase 1 homolog
• Gene Name: Ufl1 {ECO:0000312|FlyBase:FBgn0037467}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 782
• Protein Description: E3 UFM1-protein ligase that mediates ufmylation of target proteins..
• Protein Sequence: MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLEREIQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEKLVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGALAAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQVTSKQANSQYVPHIYAKTQADWVNSFYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLVELTVVTALNECSATKQYLDLTTILPSNLSEEDIEEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQALAESQAKAAIDGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSGKAGGGAQGRETKTKSTKKHQRGKAAAQFDSDDEDDAQQGSRGGGGASKKAVKPLELVKTADIVKLITASLEEEGLEHLSKSIASLYTNQFNQTALARAQELFEATPQTNRRQTHAAIQDRINTLLIDIRLYEKGLKLFPQDTQTQLVKYLLKSLGNEICNELSLYVASECNLTVKNTNLNVDQRNKLAQECEAQYRAALLEQNKALNKSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQKQLLECNEPALLLHLAALILFTTITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVLQAIPDSNESKLANEHLQTMQNQVVELAQNFSRASISKAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	Phosphorylation	LVQRGEVSISELASQ HHHCCCCCHHHHHHH	18.98	19429919
459	Phosphorylation	KAAAQFDSDDEDDAQ CCHHCCCCCCCCHHH	48.53	19429919
777	Phosphorylation	AQNFSRASISKAD-- HHHHHHHHHCCCC--	26.70	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UFL1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UFL1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UFL1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDRGK_DROME	CG5862	physical	14605208
RS7_DROME	RpS7	physical	14605208
TBA1_DROME	alphaTub84B	physical	14605208
RS15A_DROME	RpS15Aa	physical	14605208
TI50C_DROME	ttm50	physical	14605208
CCNE_DROME	CycE	physical	14605208
RLA1_DROME	RpLP1	physical	14605208
HSP7D_DROME	Hsc70-4	physical	14605208
HSP23_DROME	Hsp23	physical	14605208
SAP18_DROME	Bin1	physical	14605208
RS8_DROME	RpS8	physical	14605208
CK5P3_DROME	CG30291	physical	22036573
DDRGK_DROME	CG5862	physical	22036573
SICK_DROME	sick	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.