UniProt ID | HSP7D_DROME | |
---|---|---|
UniProt AC | P11147 | |
Protein Name | Heat shock 70 kDa protein cognate 4 | |
Gene Name | Hsc70-4 | |
Organism | Drosophila melanogaster (Fruit fly). | |
Sequence Length | 651 | |
Subcellular Localization | Cytoplasm, perinuclear region. Nucleus. Localized to a meshwork of cytoplasmic fibers around the nucleus. Translocates to the nucleus after thermal stress. | |
Protein Description | ||
Protein Sequence | MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEEVD | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
35 | N-linked_Glycosylation | IIANDQGNRTTPSYV EEECCCCCCCCCCEE | 32.28 | 17893096 | |
37 | Phosphorylation | ANDQGNRTTPSYVAF ECCCCCCCCCCEEEE | 47.24 | 23607784 | |
38 | Phosphorylation | NDQGNRTTPSYVAFT CCCCCCCCCCEEEEE | 13.65 | 22668510 | |
40 | Phosphorylation | QGNRTTPSYVAFTDT CCCCCCCCEEEEECH | 30.10 | 23607784 | |
41 | Phosphorylation | GNRTTPSYVAFTDTE CCCCCCCEEEEECHH | 9.30 | 23607784 | |
85 | Phosphorylation | FDDAAVQSDMKHWPF CCHHHHHCCCCCCCE | 32.83 | 21082442 | |
88 | Acetylation | AAVQSDMKHWPFEVV HHHHCCCCCCCEEEE | 47.73 | 21791702 | |
96 | Phosphorylation | HWPFEVVSADGKPKI CCCEEEECCCCCEEE | 26.31 | 21082442 | |
108 | Acetylation | PKIEVTYKDEKKTFF EEEEEEEECCCCCCC | 50.47 | 21791702 | |
111 | Acetylation | EVTYKDEKKTFFPEE EEEEECCCCCCCCHH | 68.21 | 21791702 | |
153 | Phosphorylation | VPAYFNDSQRQATKD EECCCCHHHCCHHCC | 28.50 | 21082442 | |
246 | Acetylation | THFVQEFKRKHKKDL HHHHHHHHHHHHCCC | 60.84 | 21791702 | |
319 | Acetylation | STMDPVEKALRDAKL HCCCHHHHHHHHCCC | 53.61 | 21791702 | |
329 | Phosphorylation | RDAKLDKSVIHDIVL HHCCCCHHHHCEEEE | 26.43 | 19429919 | |
362 | Phosphorylation | NGKELNKSINPDEAV CCHHHCCCCCHHHHH | 26.90 | 19429919 | |
511 | Phosphorylation | TNDKGRLSKEDIERM ECCCCCCCHHHHHHH | 32.41 | 22668510 | |
524 | Acetylation | RMVNEAEKYRNEDEK HHHHHHHHHCCCCHH | 57.46 | 21791702 | |
559 | Acetylation | TLDEDNLKTKISDSD EECCCCCCCCCCCCC | 54.77 | 21791702 | |
589 | Acetylation | DANQLADKEEYEHRQ CHHHCCCHHHHHHHH | 47.00 | 21791702 | |
597 | Acetylation | EEYEHRQKELEGVCN HHHHHHHHHHHHCHH | 65.31 | 21791702 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HSP7D_DROME !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HSP7D_DROME !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HSP7D_DROME !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
PSA2_DROME | Prosalpha2 | physical | 14605208 | |
CALR_DROME | Crc | physical | 14605208 | |
GAP1_DROME | RasGAP1 | genetic | 9178011 | |
OSGEP_DROME | CG4933 | physical | 22036573 | |
RS27A_DROME | RpS27A | physical | 24292889 | |
DNJC5_DROME | Csp | genetic | 11395008 | |
HLES_DROME | H | genetic | 10569241 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...
N-linked Glycosylation | |
Reference | PubMed |
"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster."; Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.; Glycobiology 17:1388-1403(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-35, AND MASS SPECTROMETRY. |