dbPTM

CK5P3_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CK5P3_DROME
UniProt AC	Q95SK3
Protein Name	CDK5RAP3-like protein {ECO:0000305}
Gene Name	CG30291 {ECO:0000312\|FlyBase:FBgn0050291}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	509
Subcellular Localization	Nucleus . Cytoplasm .
Protein Description	Probable regulator of cell proliferation. May regulate CDK5, NF-kappa-B-mediated gene transcription and p53/TP53 activation..
Protein Sequence	MNESEIPIDIHTLKLQDWLISRRIVPKNVQQELREIHRKISNALQDMPSNEQLIKLLARTNINYYHVKEIIEILKQTEKDTKSVFGTYGSQRMKDWQEISRLYEKNATYLAETAQIFVRNVNYEIPGVRKQMARLEQQADETQKRAHDLNKPESQILADHSALLEQLGVKGDNLHAEFVQVLSGLPELYDKSLVGIANIQPGIDLYAEVSGNKQVLPILNHLVEFGNTTVYQYIHKEAPLAVEEPPIRLNLSEGNASKDDNAVAEIDFGTDDNGGTSSTVSAEIIDYGDFGSGDLPESDGGNIDWGIESAPTDAVEINFDIPVEEYGIVVEGTGMDGGTAKGDQAYTLLDSPNYRDRFLDEIYELESFLRMRIYELKQLESSSDIMFSLMDNIATHDGESIWKILVSVEKIIQQTSDKQTQHLFQLKHSPKYANMLATKLQQMTKAVEKLRATREALKQLTIELREQRQDLNPVLEELIAQTRTLQSHIEKDISKRYKNRVVNLMGGVN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
257	Phosphorylation	NLSEGNASKDDNAVA ECCCCCCCCCCCCEE	40.39	29892262
415	Phosphorylation	VEKIIQQTSDKQTQH HHHHHHHCCCHHHHH	23.63	27794539
416	Phosphorylation	EKIIQQTSDKQTQHL HHHHHHCCCHHHHHH	38.17	27794539
420	Phosphorylation	QQTSDKQTQHLFQLK HHCCCHHHHHHHHHC	24.56	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CK5P3_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CK5P3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CK5P3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CK5P3_DROME

Related Literatures of Post-Translational Modification