dbPTM

STAU_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STAU_DROME
UniProt AC	P25159
Protein Name	Maternal effect protein staufen
Gene Name	stau
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1026
Subcellular Localization
Protein Description	Required both for the localization of maternal determinants to the posterior pole of the egg, oskar (osk) RNA, and for correct localization to the anterior pole, anchoring bicoid (bcd) RNA. Osk protein is required to keep osk RNA and stau protein at the posterior pole. Stau-bcd complexes form particles that show a microtubule-dependent localization..
Protein Sequence	MQHNVHAARPAPHIRAAHHHSHSHAHMHLHPGMEQHLGPSLQQQQQPPPPPQQPPHRDLHARLNHHHLHAQQQQQQQTSSNQAGAVAAAGAAYHHGNINSNSGSNISSNSNQMQKIRQQHQHLSSSNGLLGNQPPGPPPQAFNPLAGNPAALAYNQLPPHPPHHMAAHLGSYAAPPPHYYMSQAKPAKYNHYGSNANSNSGSNNSNSNYAPKAILQNTYRNQKVVVPPVVQEVTPVPEPPVTTNNATTNSTSNSTVIASEPVTQEDTSQKPETRQEPASADDHVSTGNIDATGALSNEDTSSSGRGGKDKTPMCLVNELARYNKITHQYRLTEERGPAHCKTFTVTLMLGDEEYSADGFKIKKAQHLAASKAIEETMYKHPPPKIRRSEEGGPMRTHITPTVELNALAMKLGQRTFYLLDPTQIPPTDSIVPPEFAGGHLLTAPGPGMPQPPPPPAYALRQRLGNGFVPIPSQPMHPHFFHGPGQRPFPPKFPSRFALPPPLGAHVHHGPNGPFPSVPTPPSKITLFVGKQKFVGIGRTLQQAKHDAAARALQVLKTQAISASEEALEDSMDEGDKKSPISQVHEIGIKRNMTVHFKVLREEGPAHMKNFITACIVGSIVTEGEGNGKKVSKKRAAEKMLVELQKLPPLTPTKQTPLKRIKVKTPGKSGAAAREGSVVSGTDGPTQTGKPERRKRLNPPKDKLIDMDDADNPITKLIQLQQTRKEKEPIFELIAKNGNETARRREFVMEVSASGSTARGTGNSKKLAKRNAAQALFELLEAVQVTPTNETQSSEECSTSATMSAVTAPAVEATAEGKVPMVATPVGPMPGILILRQNKKPAKKRDQIVIVKSNVESKEEEANKEVAVAAEENSNNSANSGDSSNSSSGDSQATEAASESALNTSTGSNTSGVSSNSSNVGANTDGNNHAESKNNTESSSNSTSNTQSAGVHMKEQLLYLSKLLDFEVNFSDYPKGNHNEFLTIVTLSTHPPQICHGVGKSSEESQNDAASNALKILSKLGLNNAMK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
388	Phosphorylation	PPPKIRRSEEGGPMR CCCCCCCCCCCCCCC	30.10	21082442
563	Phosphorylation	KTQAISASEEALEDS HHHHCCCCHHHHHHH	29.22	22817900
570	Phosphorylation	SEEALEDSMDEGDKK CHHHHHHHCCCCCCC	20.82	22817900
650	Phosphorylation	LQKLPPLTPTKQTPL HHHCCCCCCCCCCCC	34.38	22817900
652	Phosphorylation	KLPPLTPTKQTPLKR HCCCCCCCCCCCCCE	30.46	22817900
655	Phosphorylation	PLTPTKQTPLKRIKV CCCCCCCCCCCEEEE	31.95	22817900
676	Phosphorylation	GAAAREGSVVSGTDG CCCHHCCCEECCCCC	18.00	10698941
679	Phosphorylation	AREGSVVSGTDGPTQ HHCCCEECCCCCCCC	33.54	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STAU_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STAU_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STAU_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FMR1_DROME	Fmr1	genetic	18776892
NANOS_DROME	nos	genetic	1908748
HMG2_DROME	Dsp1	physical	23945942
HMOC_DROME	oc	physical	23945942
KDM4B_DROME	Kdm4B	physical	23945942
FLOT2_DROME	Flo2	physical	23945942
NONA_DROME	nonA	physical	23945942
CAPZB_DROME	cpb	physical	23945942
PDM1_DROME	nub	physical	23945942
STAU_DROME	stau	physical	23945942
PCKG_DROME	Pepck	physical	23945942
MED14_DROME	MED14	physical	23945942
RAS3_DROME	R	physical	23945942
VEIN_DROME	vn	physical	23945942
MRM3_DROME	CG14100	physical	23945942
KAPR1_DROME	Pka-R1	physical	23945942
PC_DROME	Pc	physical	23945942
VATE_DROME	Vha26	physical	23945942
BCD_DROME	bcd	physical	22481296
BCD_DROME	bcd	physical	23945942
OSKA_DROME	osk	physical	23945942
OSKA_DROME	osk	physical	25049271
PROS_DROME	pros	physical	23945942
PROS_DROME	pros	physical	9267024
PP4R3_DROME	flfl	physical	23945942
SQZ_DROME	sqz	physical	23945942
FUSIL_DROME	fus	physical	23945942
SPEN_DROME	spen	physical	23945942
PP4C_DROME	Pp4-19C	physical	23945942
VIR_DROME	vir	physical	23945942
CPLX_DROME	cpx	physical	27525480

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STAU_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563; SER-570; THR-650;THR-655 AND SER-676, AND MASS SPECTROMETRY.	18327897 [Abstract]