SQZ_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SQZ_DROME
• UniProt AC: Q9VDZ3
• Protein Name: Zinc finger protein squeeze
• Gene Name: sqz
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 535
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor involved in neuronal fate specification. First required in embryonic CNS development to define the number of cells that express apterous (ap) in the ap thoracic cluster of interneurons. Later on, it plays a central role in the combinatorial code of transcription factors that specifies the fate of the Tv neuron in the ap cluster by participating in the transcription regulation of FMRFa in Tv cells. Also required for projection neuron dendritic targeting..
• Protein Sequence: MAELPTAPNGVPSGDYLHRSIDQLRSLGHLTTAQLVHDYKPFNISEFRQNVAERLDYSLKNGLVQHQQQMVMEQQPHPDQQQQQHLHHPQQQQHPPQLKVSYSAPNSPPTPHEQQEQKYDPNRSPPRQQMSSASGSGSNGSSPEEESRRGDGDQAKPYKCGSCSKSFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHAGCPKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEMTLLEHIPKHKDSKHLKTHICNLCGKSYTQETYLQKHLQKHAEKAEKQQHRHTAQVAAHQQHVPASGIGLNLQRQAMNDVNAAYWAKMGADSAAASLAEAIQQQLPQAGGQPYGNFASLQQQHQQQQQELLHHQRLADTPGHSHSPHEEAAGEDLVLRQSTPQHHLQQQQQQQQQQQAQQQQQAQHQPSPGPGNSAFTPLSATVAPPPHLQQHRGPPGSAAAYLYQQNAAAAAAAFPTQLISLHQIRNYAHQPGAAGLIAGDHLALGLSAVNAAKEKAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Acetylation	AQLVHDYKPFNISEF HHHHCCCCCCCHHHH	49.55	21791702
107	Phosphorylation	VSYSAPNSPPTPHEQ EEECCCCCCCCCHHH	31.06	25749252
124	Phosphorylation	QKYDPNRSPPRQQMS HHCCCCCCCCHHHHH	45.99	22817900
395	Phosphorylation	HHQRLADTPGHSHSP HHHHHCCCCCCCCCC	26.09	19429919
399	Phosphorylation	LADTPGHSHSPHEEA HCCCCCCCCCCHHHH	31.41	19429919
401	Phosphorylation	DTPGHSHSPHEEAAG CCCCCCCCCHHHHCC	30.85	19429919
475	Phosphorylation	QHRGPPGSAAAYLYQ HCCCCCCCHHHHHHH	22.10	17372656
479	Phosphorylation	PPGSAAAYLYQQNAA CCCCHHHHHHHHHHH	10.96	17372656
481	Phosphorylation	GSAAAYLYQQNAAAA CCHHHHHHHHHHHHH	8.72	17372656

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SQZ_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SQZ_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SQZ_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of SQZ_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-395; SER-399 ANDSER-401, AND MASS SPECTROMETRY.
PubMed: 18327897

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475; TYR-479 ANDTYR-481, AND MASS SPECTROMETRY.
PubMed: 17372656