PP4R3_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PP4R3_DROME
• UniProt AC: Q9VFS5
• Protein Name: Serine/threonine-protein phosphatase 4 regulatory subunit 3
• Gene Name: flfl
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 980
• Subcellular Localization: Nucleus . Membrane . Cytoplasm . Predominantly nuclear during interphase/prophase and cytoplasmic after nuclear envelope breakdown.
• Protein Description: Regulatory subunit of serine/threonine-protein phosphatase 4. The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro). May be involved in DNA damage repair. Key mediator specific for the localization of mira and associated cell fate determinants during both interphase and mitosis. Nuclear Flfl is required to exclude mira/pros from the nucleus when inefficiently bound to the cytoskeleton/cortex, whereas cytosolic or membrane-associated flfl is required for the cortical association and asymmetric localization of mira/pros/brat/stau at metaphase and anaphase..
• Protein Sequence: MTTDTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQDTLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPPIELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFEIFKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLAKIHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTTGDAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAIVEFSPLVVRNYTLNQANRPEVERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENMLTEKGDFLNFFYKYSVQTLVAPVILNTIGDRPQNEDYQTAQLLGIVLDILSFCVEHHSYHIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPVVDAFIRNNGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQDRLKDRDKMENRTDGGLPIIRSGGRFRRDQRQMEEEEEMWFNEEDDFTEEIDTYNNVMKSVSEKNGPQTQNQQKSSPPHSTSPHSGLLGSLSTTASSTATSATSGAPVASGSSSPEAISADEQTQAAVHLAAAALQHHQQQQQQQQQNPFQQQTQPEIAELQQQLSSVEAPQSQELELSQSAAASASPTSSSSSLEASTSSSSASSSSSSSSSSSPPGSSAAASLCDSATVAAVAASQFLSTIATAMAASVTAAAATNSSPSISPAPAVSSPDIENADAQLPPSDDASSPASGEQDANSTEGTSSEADKTTAKKGLVDYESDSGEDDYEEDEYSEGPQAQKRARQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
118	Phosphorylation	TQDIVEESEDERFED EHHHHHHCCHHHCCC	36.52	19429919
953	Phosphorylation	AKKGLVDYESDSGED HHCCCCCCCCCCCCC	15.17	19429919
955	Phosphorylation	KGLVDYESDSGEDDY CCCCCCCCCCCCCCC	30.74	19429919
957	Phosphorylation	LVDYESDSGEDDYEE CCCCCCCCCCCCCCC	54.05	19429919
962	Phosphorylation	SDSGEDDYEEDEYSE CCCCCCCCCCCCCCC	33.27	23607784

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PP4R3_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PP4R3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PP4R3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP4R2_DROME	PPP4R2r	physical	25562660
PP4C_DROME	Pp4-19C	physical	25562660

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.