SPEN_DROME - dbPTM
SPEN_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPEN_DROME
UniProt AC Q8SX83
Protein Name Protein split ends
Gene Name spen
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 5560
Subcellular Localization Nucleus .
Protein Description Probable corepressor protein, which regulates different key pathways such as the EGF receptor and Wg pathways. Involved in neuronal cell fate, survival and axon guidance, cell cycle regulation and repression of head identity in the embryonic trunk. May act with the Hox gene Deformed and the EGF receptor signaling pathway. Positive regulator of the Wg pathway in larval tissues but not in embryonic tissues. May act as a transcriptional corepressor protein, which repress transcription via the recruitment of large complexes containing histone deacetylase proteins..
Protein Sequence MFRCRNMVRDNSRNICFGKLAETTTTQQQQQQQQFVVDSSTIINNNNNNNNNNNNQKLKRSTEEPPTNSFERNYYDRTTSRLVTQYQANNSTSLANSNSSPSSVSASASVFATAAGGSSERSRNRDRPYRNGSASVQGGGINSSNTTTTTAACTAGGSGSGAIGTGTGGLVGSGPGGVPQALGDRSSTQNIHQNHQSARVAPPQSWYEAATAATTAQLKSSGGSGNAGASAAVGFTMSSSPINHHPHQHPHLQNPQHPHYTSSPVVGAGSCPSAAQGQPQIQSQSQTTAVHRSVAYAGSAADDLLNTATSRNMLLHSSKLNKLLKGAGATGSGGERSGSESPGRAGGATPLTTTSTITNNSFSSNSLNNTITTATPTMPTIASGAAGSVGLGSGAEAGVCSNSGTASGDILNVAAVLAAAVDNGVPTHPIRTRHNLHGRSTTSSSRSHSRSPSSYSSSHSSSSSSHSSSHSHASSPVQSSGNCAMAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGCGSSSSSSSSSSSSGSSCLTANPVVHSEDNRPLAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDVEKALEVSHDKHFFGCKIEVEPYQGYDVEDNEFRPYEAELDEYHPKSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKKQGLNAYAFCQYSDIVSVVKAMRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQLALVLYDQVQNAQAAVKDMRGTILRRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFSRYESSASSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNACSAMPAPSLASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDFNEVGRLRFRSSEEVSGGAGNSTQFEDVRCDSPVTARQGSAVNCFTGPTAAVGESIDGTLNNNQITGGAEGFTGSGGSILSRRRCGKTPKDLHPVHNQRIQLAEQVEECPSSGDEGVVSPRKRIKMDYHHHHHHSNASGVESTGEHSSINKPSPLLLSNCDVIHDPLNRKSEIRRVSETPSGSPSIKFPGHLPSAPQSLMLSCRRPSIDVGALSALSSSSAFRHGIVGASSMDQQHMMNASAAAKRRRVTTTMQQPSSSSTTNSSSGSGLGGISSLTPADEYHHHVSRGRGHQLHSHHSHEASGGESADGSRPGTPLCDERPEVLPTEPRRLPPPRERVRERTRDVMWLPLPKFGVLFFQQQQSRSSGGGGAGNSYLQQQLGGGSTGGLGCIGAASSSACSLNNSSLNASQGMGSCSGSTFLPSPSSRYWRSSSHHQNQQNNHQQQSQQLHGSSSSNTCLMASPARPRSLSSNSSDSDVPGQNAGGSPSLDERLRNFEENYERWSGGSSREHISGHTPSSATPSWQLSMHMNLSTGLNSHQTSSASGNSNSSSGTVSSSASNSRHKFLDIDELQPSDIVKSVLAKKSVFDDDFQRLNKNQWYDPSSSDFALGSSSNIVTGSSLVANVSRHPGGPCSGNTSPALPNLAATKATPIIGNCSGGLGNSTGSKSAGLLQRLSSLSPMNSPQASMSPYNSPSPSPSVGGVTACLGQLTKPAAPGTASAGLSGGTAASSSSPAANSGPTKGLQYPFPSHPPLPNTAAPPPAVQPAPPPLPEMGKQSRLTGQSSGNNLTKSLSVPDGPQSSPARVQLQKSASVPGSTNVGAPSSLSLDSTTASVETSASISSSTSNGNSSLTSAAIHVQKPQQSTFVEEEHTKKSGTSTSQSSSSSSKKISSTHDKLHSKHNNRSESDKKIKKSDKNASSSDKRKNSSTSQSSKSATPRIEDDSSEADDTADKAEKNQRHEKEKKERQEKREKDLRKQVEREEKDRKAQQEEREKEDRKAKEEEKEREREKKAQEDREKKEREERELREKEQRDKEQKEKEIREKDLREKEQRERDNREKELRDKDLREKEMREKEQREKELHREKDQREREHREKEQSRRAMDVEQEGRGGRMRELSSYQKSKMDIAGEASSLTAIDCQHNKENAMDTIAQGTPGASPSTPSDNTPKERSRKLSRNSPVRLHKRRLSSQESNHSAGGGGSCGGSSHQIHHEDYVKRIRMENSQNISVHSSNQRLNDRRDSKEHKSSSFKEDKNSSSHISRPHGCGGSSASSSKHHHRRDKHHQKGSASSIETNSSIEVVVDPISQTKHNLNTSEEELQSHQPKREKEREHFSSHANSSSSRHKSKRDHHHHREKKRHSVAESTNTDEEHTPQQHNPHRRISAAGSGSAGELSSAATNTSSGKLHHQHHRRSVERKSSRGSDEGHHSSSKSLRAKLMMLSSADSDDTDDASKKHSIFDIPDDCPNVSMYDKVKARSCKNMQRQAEEKKIKAKFSQLKQSRAKKKRSTSYDGDSDTEFEDRQHRNSGSSSFHGRYPGLSSSDDDDDEETHQRRISSDSDAEHGGQDNQGASTLADANRVRQMQQNLRRLCDGDDSSEDEIRRNVMKHSHFGKRNSNSTRIASDSESQSQPAPDLTIKQEHPIAPAQEIKREQLSDEEQKFKSRHDSNSSIEERKLKTEREIKTELGDFYNSSEYTYTGKLKEYSPETRKKHKKSKRRLKSSSTADTSAAQTPLVMTPLTPSIFDVHSSSECKTKFDNFDDLKTECSSIPLEISAGERRKHKERKEKKREKLRNMTEATVPNSPTTNDTSSEKLSKEERHRLKKSKKSKSMDNSCNTKIYNSSGAHPSTSPSLPATPTSAPSTAQTSKRGEDKMEFIFGIISDEEESQFPEQAETNKDIIPSSVSTTGPIVSAALQTYKQEPSTPNSKNEEAHIQLTVHEPEQQQQLERSRLSGGSSSSSHADRERHRREKREKKRREKSQREQQNQIHQKSSKVETKVDDDNSVDMDEAGRALEAQLMSDFDTKPISEEATPSTAATYRSDMTDVFRFSDNEDNNSVDMTKQGVKSEQQEQHKSKDKKKKKKRSKEEKQEKLLQQQRRESLPNVASTSSAPPTPGKLTVNVQAASKHADLQLDAKHISSPPVCKPSPSLPCLIGDDDDDALHTPKAKPTTPSSRGNDGLTPSREKPRLISPIPKTPTIANSSTLSTQSAETPVSSGTVISSSALATTPTSSTAAGVSAAPGLDNSPTSASAQCKKKESFIPGFDGQLDDRISESAVQSISAEFNSTSLLDNIADEPKIPVASPPRATKPLDKLEESKSRVTISQEETESAVSALLGESFGTSSTTDYSLDGMDEMSSVNELETPTLVIAEPDEEAALAAKAIETAGEPASILEEPEMEPEREAEPDPDPEAEIESEPVVEVLDPEELNKAVQSLKHEDMMDIKADTPQSERDLQIDTDTEENPDEADSSGPSLKIDETVQSSSSPEKSISNNSPTPRETANIDIPNVESQPKLSNESTPQPSVITKLPFLDTPKTVPAGLPPSPVKIEPPTISKLQQPLVQPVQTVLPAPHSTGSGISANSVINLDLSNVISSCSNTSAASATASASASISFGSPTASQNAMPQASTPKQGPITPQQAIRTQSLIMQPPTISIPEQTPHFAVPQMVLSPQSHHPQQPGTYMVGIRAPSPHSPLHSPGRGVAQSRLVGQLSPVGRPMVSQPSPQQQVQQTQQQHALITSPQSSNISPLASPTTRVLSSSNSPTTSKVNSYQPRNQQVPQQPSPKSVAEVQTTPQLMTIPLQKMTPIQVPHHPTIISKVVTVQPQQATQSQVASSPPLGSLPPHKNVHLNAHQNQQQPQVIAKMTAHQHQQHMQQFMHQQMIQRQQHMQQQQLHGQSQQITSAPQHQMHQQHQAQQQQQHHNQQHLNQQLHAQQHPTQKQHQAQQQFNQQIQQHQSQQQHQVQQQNQAQQQHLSQQQHQSQQQLNQQHQAQQQQLQQIQKLQQMHGPQQQQKSPQGVGHLGGSTSIFASQQHNSQLPARGVPQQQHPQQLSHSSPCKPNTLVSVNQGVQPPAILTRVGSHSQPNQQQQLPHQQSSSGHPHQKQLSSPGANLPLQTPLNVIQNTPKIIVQQHIVAQNQVPPPQTQGNAIHYPQNQGKDSTPPGHVEPTPAMSAQKTSESVSVIRTPTPTTGLAVISANTVGSLLTEENLIKISQPKQDELIEQDSKEVDSDYWSAKEVNIDSVIKKLDTPLASKDAKRAVEMQAIAPAPIPNPQPGNQSMAQETALPTTSMSVNNSNDHDTEDETETRQLPPAKPPIPTVGRPPGRGGSAKRGRQPRGAKKVGGFPLNSVTAAPPGVDSLVVQPGDNGVQTRLRKPVTAPVTRGRKGRPPRNLLLQQQQLQQQQLDIQRKGMEMVTSATSSTPLPTPIPTSSVLTAAEKKARNQALTQAQEQNQVASQVGTGQDIYEFHEDGGEEPKPKTISSVAPSAEDQRPRLILTINKTQPSIKNISEMEQTIQQQQQQQSEVISNTDPIGGDNSESCNTRKSRRLQEKEDRSTVDDIIEDVVRNTNTPTGTGPHLPKGAQTPPRRSGRNAQAKKTDAVQIINAVGRPRRSKDRKTIGEQTANLIEEVTASNATVAASHLAPPEGAGVESHVPQLDAKEVEPVSVVTPISTPAPVSVAAPVTVPVPAMVPVKPTMPQHPKKKAIAAAEIESYQAINSSIPSGGLPMHQTAAPATQKITGGVADAVSKALVDPVTGVITAGMPQGKEGNLPAATAAAPANSSNEDGQAAPPPQLQHQQQQQHPQQPPQQQANLQINTTLIPSGLPNPITALGKSVQLETSAAALLNKPVSVLVKGNASQVIQQQQPQIVAPAKQPIILQQNPLPTVLHHAQHTTVRPPQPLKAHVLNREKNIQQQLTPTKQAVAQPPQHAPHSGHMLLTDTAGNQQLVQPQIIARHLQQQQHLQVNVPPPTAHSPHSPRIPSQQQQLGPGASISPQQQQPQTVVIKQAASAAQPQILHVVSSKASVVPQPQQQQLPPTSSTGPHLQLAKPNYSYAPTVLTPTLPAVQQQQQQHLYKQNNQQKGAQIQMPPHGIIMPTHPGMLLQQKLPAHLQPQQHQLNPSPPPGKPNPVLHGLQSGQIMPGSVGSPPPVSAAVLKTAQQQVNSVVPVAGIRTAIPNISPQSQPRVSPLVLPPGISGVPPFDASLHDLGAYVSGRRTQSPPPAHQQASPITPNDSTYRGVTASRDFMLYQHHLMRGGDYDDKMGSSPPLELRRPGSGPPRTIAVPHSLQSPQDRTAADSPQMAQVYVHNTRIPPAHFSEIASRGLYDSGALQLEPPPAHRPTATISVVVPQQMPAVSSGSPFIGRDGSVQPGSHHHPGKAMDMQLDEMDRMSMIAAVVQQQQEHLPPALPAGMELASQQAPPAMAPPPGDSLVTLLQRYPVMWQGLLALKTDQAAVQMHFVHGNPNVARASLPSLVETNTPLLRIAQRMRLEQTQLEGVAKKMQVDKEHCMLLALPCGRDHADVLQHSRNLQTGFITYLQQKMAAGIVNIPIPGSEQAAYVVHIFPSCDFANENLERAAPDLKNRVAELAHLLIVIATV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
848PhosphorylationQSRSRASSFSRHQNN
HHHHHHHHHHCCCCC		26.6825749252
1137PhosphorylationKSEIRRVSETPSGSP
HHHHEEEECCCCCCC		33.6622817900
1139PhosphorylationEIRRVSETPSGSPSI
HHEEEECCCCCCCCC		18.4322817900
1145PhosphorylationETPSGSPSIKFPGHL
CCCCCCCCCCCCCCC		39.8622817900
1167PhosphorylationMLSCRRPSIDVGALS
HHHCCCCCCCHHHHH		29.6121082442
1174PhosphorylationSIDVGALSALSSSSA
CCCHHHHHHHCCCHH		26.9918327897
1178PhosphorylationGALSALSSSSAFRHG
HHHHHHCCCHHHHCC		29.2122817900
1596PhosphorylationRHPGGPCSGNTSPAL
CCCCCCCCCCCCCCC		37.9122817900
1600PhosphorylationGPCSGNTSPALPNLA
CCCCCCCCCCCCCHH		16.5122817900
1756PhosphorylationNNLTKSLSVPDGPQS
CCCCCCEECCCCCCC		38.4027794539
1907PhosphorylationTPRIEDDSSEADDTA
CCCCCCCCCCCCHHH		42.2619429919
1908PhosphorylationPRIEDDSSEADDTAD
CCCCCCCCCCCHHHH		43.7419429919
2121PhosphorylationAQGTPGASPSTPSDN
HCCCCCCCCCCCCCC		25.8727794539
2138PhosphorylationKERSRKLSRNSPVRL
HHHHHHHHCCCHHHH		32.2425749252
2141PhosphorylationSRKLSRNSPVRLHKR
HHHHHCCCHHHHHHH		24.5425749252
2151PhosphorylationRLHKRRLSSQESNHS
HHHHHHCCCCCCCCC		28.3222817900
2152PhosphorylationLHKRRLSSQESNHSA
HHHHHCCCCCCCCCC		42.4322817900
2155PhosphorylationRRLSSQESNHSAGGG
HHCCCCCCCCCCCCC		32.0022817900
2158PhosphorylationSSQESNHSAGGGGSC
CCCCCCCCCCCCCCC		32.6222817900
2276PhosphorylationQTKHNLNTSEEELQS
HCCCCCCCCHHHHHH		40.4519429919
2277PhosphorylationTKHNLNTSEEELQSH
CCCCCCCCHHHHHHC		41.7719429919
2326PhosphorylationKRHSVAESTNTDEEH
HHHHHHCCCCCCCCC		19.7422668510
2329PhosphorylationSVAESTNTDEEHTPQ
HHHCCCCCCCCCCCC		44.8922817900
2345PhosphorylationHNPHRRISAAGSGSA
CCCCCCEECCCCCCH		15.3922817900
2349PhosphorylationRRISAAGSGSAGELS
CCEECCCCCCHHHCC		25.5022817900
2351PhosphorylationISAAGSGSAGELSSA
EECCCCCCHHHCCCC		34.4922817900
2403PhosphorylationRAKLMMLSSADSDDT
HHHHHHHHCCCCCCC		12.9419429919
2404PhosphorylationAKLMMLSSADSDDTD
HHHHHHHCCCCCCCC		31.9419429919
2407PhosphorylationMMLSSADSDDTDDAS
HHHHCCCCCCCCCHH		36.7819429919
2410PhosphorylationSSADSDDTDDASKKH
HCCCCCCCCCHHHHC		40.5519429919
2414PhosphorylationSDDTDDASKKHSIFD
CCCCCCHHHHCCCCC		49.5919429919
2469PhosphorylationSRAKKKRSTSYDGDS
HHHHHCCCCCCCCCC		30.5019429919
2470PhosphorylationRAKKKRSTSYDGDSD
HHHHCCCCCCCCCCC		35.0319429919
2471PhosphorylationAKKKRSTSYDGDSDT
HHHCCCCCCCCCCCC		23.6019429919
2472PhosphorylationKKKRSTSYDGDSDTE
HHCCCCCCCCCCCCC		24.8419429919
2476PhosphorylationSTSYDGDSDTEFEDR
CCCCCCCCCCCCCHH		52.5419429919
2478PhosphorylationSYDGDSDTEFEDRQH
CCCCCCCCCCCHHHH		46.6719429919
2488PhosphorylationEDRQHRNSGSSSFHG
CHHHHCCCCCCCCCC		39.7521082442
2501PhosphorylationHGRYPGLSSSDDDDD
CCCCCCCCCCCCCCC		33.4422817900
2502PhosphorylationGRYPGLSSSDDDDDE
CCCCCCCCCCCCCCH		42.7122817900
2503PhosphorylationRYPGLSSSDDDDDEE
CCCCCCCCCCCCCHH		41.5022817900
2517PhosphorylationETHQRRISSDSDAEH
HHHHHHHCCCCCCCC		26.7019429919
2518PhosphorylationTHQRRISSDSDAEHG
HHHHHHCCCCCCCCC		38.4719429919
2520PhosphorylationQRRISSDSDAEHGGQ
HHHHCCCCCCCCCCC		40.4419429919
2557PhosphorylationRLCDGDDSSEDEIRR
HHCCCCCCCHHHHHH		40.1319429919
2558PhosphorylationLCDGDDSSEDEIRRN
HCCCCCCCHHHHHHH		56.9419429919
2584PhosphorylationSNSTRIASDSESQSQ
CCCCCCCCCCCCCCC		39.0219429919
2586PhosphorylationSTRIASDSESQSQPA
CCCCCCCCCCCCCCC		36.3319429919
2588PhosphorylationRIASDSESQSQPAPD
CCCCCCCCCCCCCCC		38.8019429919
2616PhosphorylationEIKREQLSDEEQKFK
HHHHHHCCHHHHHHH		42.5419429919
2624PhosphorylationDEEQKFKSRHDSNSS
HHHHHHHHHCCCCCH		37.6719429919
2628PhosphorylationKFKSRHDSNSSIEER
HHHHHCCCCCHHHHH		32.2719429919
2630PhosphorylationKSRHDSNSSIEERKL
HHHCCCCCHHHHHHH		36.3219429919
2631PhosphorylationSRHDSNSSIEERKLK
HHCCCCCHHHHHHHH		37.9719429919
2666PhosphorylationTGKLKEYSPETRKKH
CCCCCCCCHHHHHHH		19.8325749252
2669PhosphorylationLKEYSPETRKKHKKS
CCCCCHHHHHHHHHH		51.6927626673
2764PhosphorylationTEATVPNSPTTNDTS
CCCCCCCCCCCCCCC		19.9723607784
2766PhosphorylationATVPNSPTTNDTSSE
CCCCCCCCCCCCCCH		37.7423607784
2767PhosphorylationTVPNSPTTNDTSSEK
CCCCCCCCCCCCCHH		34.1923607784
2770PhosphorylationNSPTTNDTSSEKLSK
CCCCCCCCCCHHCCH		35.9023607784
2771PhosphorylationSPTTNDTSSEKLSKE
CCCCCCCCCHHCCHH		39.0923607784
2772PhosphorylationPTTNDTSSEKLSKEE
CCCCCCCCHHCCHHH		40.6223607784
2809PhosphorylationNSSGAHPSTSPSLPA
CCCCCCCCCCCCCCC		31.4821082442
2917PhosphorylationRSRLSGGSSSSSHAD
HHHHCCCCCCCHHHH		30.4922817900
2965PhosphorylationTKVDDDNSVDMDEAG
ECCCCCCCCCHHHHH		26.8719429919
3011PhosphorylationMTDVFRFSDNEDNNS
CCCEEECCCCCCCCC		34.9619429919
3018PhosphorylationSDNEDNNSVDMTKQG
CCCCCCCCCCHHHHH		26.2519429919
3100PhosphorylationQLDAKHISSPPVCKP
ECCCCCCCCCCCCCC		36.1921082442
3101PhosphorylationLDAKHISSPPVCKPS
CCCCCCCCCCCCCCC		32.4022817900
3125PhosphorylationDDDDALHTPKAKPTT
CCCCCCCCCCCCCCC		27.6018327897
3152PhosphorylationREKPRLISPIPKTPT
CCCCCCCCCCCCCCC		22.7422817900
3264PhosphorylationEPKIPVASPPRATKP
CCCCCCCCCCCCCCC		35.3522817900
3408PhosphorylationMMDIKADTPQSERDL
HCCCCCCCCCHHHCC		28.2522817900
3411PhosphorylationIKADTPQSERDLQID
CCCCCCCHHHCCCCC		35.4822817900
3443PhosphorylationKIDETVQSSSSPEKS
CCCCCCCCCCCCCHH		28.0522817900
3444PhosphorylationIDETVQSSSSPEKSI
CCCCCCCCCCCCHHH		20.1122817900
3446PhosphorylationETVQSSSSPEKSISN
CCCCCCCCCCHHHCC		38.7427794539
3455PhosphorylationEKSISNNSPTPRETA
CHHHCCCCCCCHHHC		34.1119429919
3457PhosphorylationSISNNSPTPRETANI
HHCCCCCCCHHHCCC		34.5019429919
3650PhosphorylationMVGIRAPSPHSPLHS
EEEEECCCCCCCCCC		33.9722817900
3653PhosphorylationIRAPSPHSPLHSPGR
EECCCCCCCCCCCCC		32.3222817900
3657PhosphorylationSPHSPLHSPGRGVAQ
CCCCCCCCCCCCHHH		36.4122817900
3672PhosphorylationSRLVGQLSPVGRPMV
HHHCCCCCCCCCCCC		15.0622817900
3707PhosphorylationSPQSSNISPLASPTT
CCCCCCCCCCCCCCC		20.3622817900
3722PhosphorylationRVLSSSNSPTTSKVN
EEECCCCCCCCCCCC		26.1021082442
3743PhosphorylationQQVPQQPSPKSVAEV
CCCCCCCCCCCHHCC		40.3930478224
4065PhosphorylationHPHQKQLSSPGANLP
CCCHHHCCCCCCCCC		31.8027794539
4066PhosphorylationPHQKQLSSPGANLPL
CCHHHCCCCCCCCCC		35.6328490779
4544PhosphorylationHLPKGAQTPPRRSGR
CCCCCCCCCCCCCCC		34.4222817900
4938PhosphorylationPTAHSPHSPRIPSQQ
CCCCCCCCCCCCHHC		21.1810655223
4955PhosphorylationLGPGASISPQQQQPQ
CCCCCCCCCCCCCCC		17.7330478224
5118PhosphorylationVSAAVLKTAQQQVNS
CCHHHHHHHHHHHHC		26.0722817900
5227PhosphorylationYDDKMGSSPPLELRR
CCCCCCCCCCCCCCC		25.4722668510
5237PhosphorylationLELRRPGSGPPRTIA
CCCCCCCCCCCCEEE		51.3022817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPEN_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPEN_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPEN_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
Y3427_DROMECG43427physical
14605208
NOTCH_DROMENgenetic
10835395
MYO7A_DROMEckgenetic
15596016
SPITZ_DROMEspigenetic
10959845
TSH_DROMEtshgenetic
10556062
ANTP_DROMEAntpgenetic
10556062
RAS1_DROMERas85Dgenetic
10959845
HLES_DROMEHgenetic
10835395
PNT1_DROMEpntgenetic
10959845
PNT2_DROMEpntgenetic
10959845
TRR_DROMEtrrphysical
26912830
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPEN_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1174; SER-1596;SER-1600; SER-1907; SER-1908; THR-2276; SER-2277; THR-2329; SER-2345;SER-2349; SER-2351; SER-2403; SER-2404; SER-2407; THR-2410; SER-2476;THR-2478; SER-2501; SER-2502; SER-2503; SER-2517; SER-2518; SER-2520;SER-2557; SER-2558; SER-2584; SER-2586; SER-2588; SER-3011; SER-3018;THR-3125; THR-3408; SER-3411; SER-3650; SER-3653; SER-3657; SER-3672;SER-3707 AND SER-4938, AND MASS SPECTROMETRY.

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