dbPTM

OSKA_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OSKA_DROME
UniProt AC	P25158
Protein Name	Maternal effect protein oskar
Gene Name	osk
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	606
Subcellular Localization
Protein Description	Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole..
Protein Sequence	MAAVTSEFPSKPISYTSTNTSAKTYYLKSVKKRVTTCFQQLRDKLQSSGSFRKSSSSCLNQIFVRSDFSACGERFRKIFKSARKTELPELWKVPLVAHELTSRQSSQQLQVVARLFSSTQISTKEITYNSNSNTSENNMTIIESNYISVREEYPDIDSEVRAILLSHAQNGITISSIKSEYRKLTGNPFPLHDNVTDFLLTIPNVTAECSESGKRIFNLKASLKNGHLLDMVLNQKERTSDYSSGAPSLENIPRAPPRYWKNPFKRRALSQLNTSPRTVPKITDEKTKDIATRPVSLHQMANEAAESNWCYQDNWKHLNNFYQQASVNAPKMPVPINIYSPDAPEEPINLAPPGHQPSCRTQSQKTEPTENRHLGIFVHPFNGMNIMKRRHEMTPTPTILTSGTYNDSLLTINSDYDAYLLDFPLMGDDFMLYLARMELKCRFRRHERVLQSGLCVSGLTINGARNRLKRVQLPEGTQIIVNIGSVDIMRGKPLVQIEHDFRLLIKEMHNMRLVPILTNLAPLGNYCHDKVLCDKIYRFNKFIRSECCHLKVIDIHSCLINERGVVRFDCFQASPRQVTGSKEPYLFWNKIGRQRVLQVIETSLEY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
270	Phosphorylation	PFKRRALSQLNTSPR HHHHHHHHHCCCCCC	31.47	22817900
274	Phosphorylation	RALSQLNTSPRTVPK HHHHHCCCCCCCCCC	49.02	28490779
275	Phosphorylation	ALSQLNTSPRTVPKI HHHHCCCCCCCCCCC	16.00	28490779
326	Phosphorylation	NNFYQQASVNAPKMP HHHHHHHHCCCCCCC	16.15	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OSKA_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OSKA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OSKA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNG6_DROME	Tango6	physical	14605208
JMJD6_DROME	PSR	physical	14605208
RB27C_DROME	Hrb27C	genetic	15130489
AUB_DROME	aub	genetic	8625849
AUB_DROME	aub	genetic	8952062
AUB_DROME	aub	genetic	11526087
ESCA_DROME	esg	genetic	18641633
VLS_DROME	vls	genetic	15800004
SMD3_DROME	SmD3	genetic	20570937
ANM5_DROME	csul	genetic	17164419
STAU_DROME	stau	genetic	10716936
LASP1_DROME	Lasp	genetic	19036801
NANOS_DROME	nos	genetic	1908748
NANOS_DROME	nos	genetic	8895661
NANOS_DROME	nos	genetic	8952062
ACTN_DROME	Actn	physical	27923120
ACT1_DROME	Act5C	physical	27923120
SWA_DROME	swa	physical	27923120
ORK1_DROME	Ork1	physical	27923120
TNNT_DROME	up	physical	27923120
SPTCB_DROME	beta-Spec	physical	27923120
TNNI_DROME	wupA	physical	27923120
CAPZB_DROME	cpb	physical	27923120
DUOX_DROME	Duox	physical	27923120
RL15_DROME	RpL15	physical	27923120
MYSA_DROME	Mhc	physical	27923120
CL190_DROME	CLIP-190	physical	27923120
ACT2_DROME	Act42A	physical	27923120
GCL_DROME	gcl	physical	26190108
1433Z_DROME	14-3-3zeta	physical	27923120
STAU_DROME	stau	physical	8804312
ACT3_DROME	Act57B	physical	27923120
CAPZA_DROME	cpa	physical	27923120
TUD_DROME	tud	physical	27923120
MYSN_DROME	zip	physical	27923120
CUE_DROME	cue	physical	27923120
PH4H_DROME	Hn	physical	27923120
MYSP1_DROME	Prm	physical	27923120
MYSP2_DROME	Prm	physical	27923120
SMG_DROME	smg	physical	21081899
LASP1_DROME	Lasp	physical	19036801
ACT4_DROME	Act79B	physical	27923120
OSKA_DROME	osk	physical	26190108
HYD_DROME	hyd	physical	27923120
CAD87_DROME	Cad87A	physical	27923120
TPM1_DROME	Tm1	physical	27923120
TPM4_DROME	Tm1	physical	27923120
TPM2_DROME	Tm2	physical	27923120
ACT6_DROME	Act88F	physical	27923120
NANOS_DROME	nos	physical	26190108
MYS9_DROME	jar	physical	27923120
LOLA1_DROME	lola	physical	27923120
LOLA2_DROME	lola	physical	27923120
LOLA3_DROME	lola	physical	27923120
LOLA4_DROME	lola	physical	27923120
LOLA6_DROME	lola	physical	27923120
LOLA5_DROME	lola	physical	27923120
GELS_DROME	Gel	physical	27923120
LARP_DROME	larp	physical	27923120

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OSKA_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270 AND SER-275, ANDMASS SPECTROMETRY.	18327897 [Abstract]