ORK1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ORK1_DROME
• UniProt AC: Q94526
• Protein Name: Open rectifier potassium channel protein 1
• Gene Name: Ork1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1001
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Background potassium channel. Rectification is dependent on external potassium concentration. Acts as an outwardly rectifying channel but as external potassium levels increase, this is reversed..
• Protein Sequence: MSPNRWILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVNGILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLLLPSWVFTYFENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYLVMIMTFITRGLQSKKLAYLEQQLSSNLKATQNRIWSGVTKDVGYLRRMLNELYILKVKPVYTDVDIAYTLPRSNSCPDLSMYRVEPAPIPSRKRAFSVCADMVAAQREAGMVHANSDTELSKLDREKTFETAEAYRQTTDLLAKVVNALATVKPPPAEQEDAALYGGYHGFSDSQILASEWSFSTVNEFTSPRRPRARACSDFNLEAPRWQSERPLRSSHNEWTWSGDNQQIQEAFNQRYKGQQRANGAANSTMVHLEPDALEEQLKKQSPGAGRVKKFSMPDGLRRLFPFQKKRPSQDLERKLSVVSVPEGVISQQARSPLDYYSNTVTAASSQSYLRNGRGPPPPFESNGSLASGGGGLTNMGFQMEDGATPPSALGGGAYQRKAAAGKRRRESIYTQNQAPSARRGSMYPPTAHALAQMQMRRGSLATSGSGSAAMAAVAARRGSLFPATASASSLTSAPRRSSIFSVTSEKDMNVLEQTTIADLIRALEVVHTHAVLDEQQQAAAAGGAAGGGGISRGSRKQRKMGNAGLEPPQLPPILSLFAGDQTRTLQAAAANRLYARRSTIVGISPTGGAATAPAARSLLEPPPSYTERAANQSQITAGPSNAPTVQSKFRRRFSVRPTALQIPPGQAPPPGASLMEQSSQTALQRRLSLRPSPLARELSPTSPPGGSGSALPAGAIDESGGTSAQRLLPLPAGTRPSTSSTHSPLSRIVQISQAQRKSSMPSAAATGSSGAPAEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	N-linked_Glycosylation	LEELGDKNTTTQDEI HHHHCCCCCCCHHHH	47.61	-
332	Phosphorylation	YTLPRSNSCPDLSMY EECCCCCCCCCCCEE	28.42	22817900
373	Phosphorylation	AGMVHANSDTELSKL HCCCCCCCCCHHHHC	46.85	30478224
458	Phosphorylation	RPRARACSDFNLEAP CCCCCCCCCCCCCCC	44.23	28490779
527	Phosphorylation	EEQLKKQSPGAGRVK HHHHHHCCCCCCCCC	33.89	27794539
562	Phosphorylation	QDLERKLSVVSVPEG HHHHHHHEEEECCCC	24.41	28490779
565	Phosphorylation	ERKLSVVSVPEGVIS HHHHEEEECCCCHHC	29.78	28490779
685	Phosphorylation	QMQMRRGSLATSGSG HHHHHHCCCCCCCCH	17.02	18327897
691	Phosphorylation	GSLATSGSGSAAMAA CCCCCCCCHHHHHHH	29.37	18327897
715	Phosphorylation	PATASASSLTSAPRR CCCCCHHHCCCCCCC	35.07	18327897
830	Phosphorylation	RSTIVGISPTGGAAT CCEEEEECCCCCCCC	15.52	28490779
925	Phosphorylation	SPLARELSPTSPPGG CCCHHHCCCCCCCCC	22.75	28490779
927	Phosphorylation	LARELSPTSPPGGSG CHHHCCCCCCCCCCC	50.95	28490779
928	Phosphorylation	ARELSPTSPPGGSGS HHHCCCCCCCCCCCC	32.26	30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ORK1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ORK1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ORK1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332; SER-373; SER-562;SER-565; SER-685; SER-691 AND SER-715, AND MASS SPECTROMETRY.
PubMed: 18327897