SMG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMG_DROME
• UniProt AC: Q23972
• Protein Name: Protein Smaug
• Gene Name: smg
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 999
• Subcellular Localization: Cytoplasm . In the cytoplasm of syncytial embryos, accumulates in discrete foci.
• Protein Description: Translation regulator that binds to the 3'-UTR of specific mRNAs such as nanos (nos) and prevents their translation. Prevents translation of unlocalized nos in the bulk cytoplasm via the recruitment of cup..
• Protein Sequence: MKYATGTDNAMTSGISGQTNNSNSASNEMQPTTSTPTAAHKEATSTATTTATYANGNPNSNANPSQSQPSNALFCEQVTTVTNLFEKWNDCERTVVMYALLKRLRYPSLKFLQYSIDSNLTQNLGTSQTNLSSVVIDINANNPVYLQNLLNAYKTFQPCDLLDAMSSSSSDKDSMPCYGSDFQITTSAQCDERKLYARKEDILHEVLNMLPLLKPGNEEAKLIYLTLIPVAVKDTMQQIVPTELVQQIFSYLLIHPAITSEDRRSLNIWLRHLEDHIQAAAAGLTNRSYFLQPSPQLVAGGSSTGSGSCSSSATSSSTASCSSVASSSLCPASGSRSSRTNDWQTIAPPSKQLQNKLAGDWRGNGGGSSSGSINPLCDNLNGITLNELASSQNSLGLSLEGSSSLVNGVVAGAGSMLGIAGGDDHDTSFSKNGTEILDFDPVTADMGEACSLASSSLCGRNGGNPVEDRSQPPPNLQQQLLQPPPYASILMGNVGDQFGEINRWSLDSKIAALKTRRSNSLTTQTISSCSSSSNSSVITVNDNCSNSTENLAQFANKPRSFSLSIEHQRGALMNSGSDTRLDEFKPNYIKFHTRNVGMSGIGLWLKSLRLHKYIELFKNMTYEEMLLITEDFLQSVGVTKGASHKLALCIDKLKERANILNRVEQELLSGQMELSTAVEELTNIVLTPMKPLESPGPPEENIGLRFLKVIDIVTNTLQQDPYAVQDDETLGVLMWILDRSIHNEAFMNHASQLKDLKFKLSKMKISMVPKMHHVKPAGVGPNNGNINKPRWNGKTRKCDTKNGSNDRINNRKNSNDMLNFSLNCLPHPLPHHSQQAPPPLPQFDYNGYGGGPSHQPQYKSSSYPSFMGNPQQQPPPPPSSKSHHHPQQMQQMLQQHNHFPALPQQTPPQSHRRSLNNLILVAGGPQQPQQLIFKPGQGVLTNNGSNDNLVLERNQQSQQQQQQRKLSGGVSSAEQQPKKTMAAVVMENLAKFDQHFTLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
562	Phosphorylation	ANKPRSFSLSIEHQR CCCCCCEECEEEHHH	23.58	22817900
564	Phosphorylation	KPRSFSLSIEHQRGA CCCCEECEEEHHHCC	25.40	22817900
575	Phosphorylation	QRGALMNSGSDTRLD HHCCCCCCCCCCCHH	26.21	18327897
682	Phosphorylation	STAVEELTNIVLTPM HHHHHHHHCCCCCCC	26.61	22668510
687	Phosphorylation	ELTNIVLTPMKPLES HHHCCCCCCCCCCCC	15.50	22668510
694	Phosphorylation	TPMKPLESPGPPEEN CCCCCCCCCCCCHHH	42.72	22668510
967	Phosphorylation	QQQQRKLSGGVSSAE HHHHHHHHCCCCCHH	36.21	22817900
972	Phosphorylation	KLSGGVSSAEQQPKK HHHCCCCCHHHCCCH	33.16	12820967

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMG_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIS1_DROME	Lis-1	physical	14605208
CUP_DROME	cup	physical	14685270
NDUS1_DROME	ND75	physical	25816335
SDHB_DROME	SdhB	physical	25816335
SDHA_DROME	SdhA	physical	25816335
ATPK_DROME	CG4692	physical	25816335
ORB2_DROME	orb2	physical	22284910
AGO2_DROME	AGO2	physical	23184089
CAF1_DROME	Caf1	physical	17050620
NANOS_DROME	nos	physical	17050620
NANOS_DROME	nos	physical	10606265
NANOS_DROME	nos	physical	21081899
NANOS_DROME	nos	physical	8895661
NDUAA_DROME	ND42	physical	25816335
DHSD_DROME	CG10219	physical	25816335
ATPB_DROME	ATPsyn-beta	physical	25816335
IF4E_DROME	eIF-4E	physical	14685270
COX7A_DROME	CG9603	physical	25816335

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-564; SER-575 ANDSER-972, AND MASS SPECTROMETRY.
PubMed: 18327897