NDUS1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUS1_DROME
• UniProt AC: Q94511
• Protein Name: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
• Gene Name: ND-75 {ECO:0000312|FlyBase:FBgn0017566}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 731
• Subcellular Localization: Mitochondrion inner membrane. Matrix and cytoplasmic side of the mitochondrial inner membrane..
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity)..
• Protein Sequence: MIRAPLVKALGALGSPTHQMASRAVRTSAMVAQTPAKAPEKIEVFVDDIPVQVVPGTTVLQAAAQIGVEIPRFCYHERLAVAGNCRMCLVEVEKSPKPVAACAMPVMKGWRIKTNSDLTRKAREGVMEFLLMNHPLDCPICDQGGECDLQDQAMAFGSDRSRFTDINYTGKRAVEDKDIGPLVKTIMTRCIHCTRCVRFASEIAGVDDLGTTGRGNDMQIGTYVEKLFLTELSGNVIDLCPVGALTNKPYSFVARPWEIRKVSSIDVLDAVGSNIVVSTRTNEVLRILPRENEDVNEEWLADKSRFACDGLKRQRLVAPMVRMPNGELQAVEWEGALIAVAKAIKAAGGQIAGISGQLADLEAQVALKDLLNRLGSEVVATEQGFIAGGTDNRANYLLNSTIAGLEEADAVLLVGTNPRYEAPLVNTRLRKAYVHNELQIASIGPKIDLSYDHENLGADAALVKDVCSGAHAFSKVLEGAKKPAIIIGADLLERADGAAIHATVAEYCKKLKKPNWNPFNVLQTNAAQVGALDVGYKAGAQTAVKAQPKVLFLLNADAGKVTREQLPKDCFVVYIGSHGDNGASIADAVLPGAAYTEKQGIYVNTEGRPQQTLPGVSPPGMAREDWKILRALSEVVGKPLPYDNLDELRNRLEDVAPHLTRLGQLEPAGDAGAAGTISKSIGGGAIDIKLKELRDYFMTDAISRASPTMAKCISAVNKQQRENEAKQSVAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
95	Phosphorylation	CLVEVEKSPKPVAAC EEEEECCCCCCCEEE	25.34	22817900
263	Phosphorylation	PWEIRKVSSIDVLDA CCEEEECCEEEEEHH	25.31	28490779
264	Phosphorylation	WEIRKVSSIDVLDAV CEEEECCEEEEEHHC	26.29	28490779
680	Phosphorylation	AAGTISKSIGGGAID CCCCCHHHCCCCCEE	21.48	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUS1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUS1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUS1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VINC_DROME	Vinc	physical	14605208
JMJD6_DROME	PSR	physical	22036573
LST8_DROME	Lst8	physical	22036573
SPITZ_DROME	spi	genetic	22134547
SODM_DROME	Sod2	genetic	22134547
FOXO_DROME	foxo	genetic	22134547
AKT1_DROME	Akt1	genetic	22134547

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.