SDHB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDHB_DROME
• UniProt AC: P21914
• Protein Name: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
• Gene Name: SdhB
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 297
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
• Protein Description: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)..
• Protein Sequence: MLATEARQILSRVGSLVARNQMRAISNGTAQLEQQAQPKEAQEPQIKKFEIYRWNPDNAGEKPYMQTYEVDLRECGPMVLDALIKIKNEMDPTLTFRRSCREGICGSCAMNIGGTNTLACISKIDINTSKSLKVYPLPHMYVVRDLVPDMNNFYEQYRNIQPWLQRKNEAGEKKGKAQYLQSVEDRSKLDGLYECILCACCSTSCPSYWWNAEKYLGPAVLMQAYRWIIDSRDENSAERLNKLKDPFSVYRCHTIMNCTRTCPKGLNPGRAIAEIKKLLSGLASKPAPKLETAALHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
285	Ubiquitination	LLSGLASKPAPKLET HHHHHHCCCCCCCCH		31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDHB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDHB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDHB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED9_DROME	MED9	physical	14605208
SDHA_DROME	SdhA	physical	25023514

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.